The action of neuropeptide AF on passive avoidance learning. Involvement of neurotransmitters
| Autor: | Gyula Telegdy, Zsolt Bagosi, Miklos Palotai, Miklós Jászberényi |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine medicine.drug_class Cognitive Neuroscience Methysergide Experimental and Cognitive Psychology (+)-Naloxone Cyproheptadine Mice 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Opioid receptor Muscarinic acetylcholine receptor Avoidance Learning medicine Animals Memory Consolidation Neurotransmitter Agents Amyloid beta-Peptides Antagonist Receptor antagonist 030104 developmental biology 5-HT1 receptor Psychology Oligopeptides Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neurobiology of Learning and Memory. 127:34-41 |
| ISSN: | 1074-7427 |
| DOI: | 10.1016/j.nlm.2015.11.011 |
| Popis: | Neuropeptide AF (NPAF) is an amidated octadecapeptide, which is member of the RFamide peptide family. NPAF is encoded by the farp-1 gene and acts through the G protein coupled NPFF-1 and NPFF-2 receptors. NPAF is involved in several physiological functions of the central nervous system, however we have little evidence about the involvement of NPAF in learning and memory. Therefore, the aim of the present study was to investigate the action of NPAF on consolidation of memory in a passive avoidance learning paradigm in mice. We have also investigated the underlying neurotransmissions and the action of NPAF on β-amyloid-induced memory impairment. Accordingly, mice were pretreated with a nonselective muscarinic acetylcholine receptor antagonist, atropine, a non-selective 5-HT2 serotonergic receptor antagonist, cyproheptadine, a mixed 5-HT1/5-HT2 serotonergic receptor antagonist, methysergide, a D2, D3, D4 dopamine receptor antagonist, haloperidol, a non-selective opioid receptor antagonist, naloxone, a nitric oxide synthase inhibitor, nitro-l-arginine, a α1/α2β-adrenergic receptor antagonist, prazosin, a nonselective β-adrenergic receptor antagonist, propranolol or β-amyloid 25-35 in combination with NPAF administration. Our results demonstrate for the first time that NPAF improves the consolidation of passive avoidance learning. This effect is mediated through muscarinic cholinergic, 5HT1- and 5HT2-serotoninergic, dopaminergic, nitrergic and α- and β-adrenergic neurotransmissions, but not by opioid transmission, since atropine, cyproheptadine, methysergide, haloperidol, nitro-l-arginine, prazosin and propranolol reversed the action of NPAF, whereas naloxone was ineffective. The present study also shows that NPAF reverses the β-amyloid 25-35-induced memory impairment. |
| Databáze: | OpenAIRE |
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