Inflammatory cytokines in BAL fluid and pulmonary hemodynamics in high-altitude pulmonary edema
| Autor: | Keisaku Fujimoto, Takashige Miyahara, Toshio Kobayashi, Masayuki Hanaoka, Toshihide Hayano, Tomonobu Koizumi, Muneharu Hayasaka, Takayuki Honda, Tsutomu Hachiya, Keishi Kubo |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Pulmonary Circulation Pathology medicine.medical_specialty Physiology Pulmonary Edema Proinflammatory cytokine Edema High-altitude pulmonary edema medicine Humans Hypoxia Pulmonary wedge pressure Lung medicine.diagnostic_test business.industry Hemodynamics Pulmonary edema medicine.disease Pulmonary hypertension Oxygen Bronchoalveolar lavage medicine.anatomical_structure Cytokines Inflammation Mediators medicine.symptom business Bronchoalveolar Lavage Fluid |
| Zdroj: | Respiration Physiology. 111:301-310 |
| ISSN: | 0034-5687 |
| Popis: | To evaluate the pathogenesis of high-altitude pulmonary edema (HAPE), we performed bronchoalveolar lavage (BAL) and pulmonary hemodynamic studies in seven patients with HAPE at its early stage. We measured cell counts, biochemical contents, and concentrations of pro-inflammatory cytokines including interleukin (IL)-1, IL-6, IL-8 and tumor necrosis factor (TNF)-alpha and of anti-inflammatory cytokines including IL-1 receptor antagonist (ra) and IL-10 in the BAL fluid (BALF). All patients showed increased counts for total cells, alveolar macrophages, neutrophils and lymphocytes, and markedly elevated concentrations of proteins, lactate dehydrogenase, IL-1beta, IL-6, IL-8, TNF-alpha and IL-1ra. The levels of IL-1alpha and IL-10 were not increased. Patients also showed pulmonary hypertension with normal wedge pressure. Both the driving pressure obtained as pulmonary arterial pressure minus wedge pressure and the PaO2 under room air were significantly correlated with the concentrations of IL-6 and TNF-alpha in the BALF. These findings suggest that the inflammatory cytokines play a role at the early stage of HAPE and might be related to pulmonary hypertension. |
| Databáze: | OpenAIRE |
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