Social integration and inflammation in individuals with and without posttraumatic stress disorder

Autor: Thomas C. Neylan, J. Lin, Aoife O'Donovan, Joshua D. Woolley, Ashkan J. Ahmadian, Beth E. Cohen
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
Clinician Administered PTSD Scale
Stress Disorders
Post-Traumatic
Behavioral Neuroscience
Perceived Social Support
0302 clinical medicine
Social integration
Psychology
Medicine
Posttraumatic Stress Disorder
Social isolation
Stress Disorders
Veterans
PTSD
Middle Aged
Post-Traumatic Stress Disorder (PTSD)
Anxiety Disorders
Mental Health
Social Isolation
Social Network
Female
medicine.symptom
Clinical psychology
Immunology
Inflammation
behavioral disciplines and activities
Article
03 medical and health sciences
Social support
Clinical Research
Behavioral and Social Science
mental disorders
Humans
Social Integration
Veterans Affairs
Aged
Neurology & Neurosurgery
Social network
Endocrine and Autonomic Systems
business.industry
Neurosciences
Social Support
Brain Disorders
Posttraumatic stress
Good Health and Well Being
030104 developmental biology
Immune System
Post-Traumatic
business
030217 neurology & neurosurgery
Zdroj: Brain Behav Immun
ISSN: 0889-1591
Popis: BackgroundPosttraumatic stress disorder (PTSD) is associated with increased risk for morbidity and mortality, which may be mediated through elevated inflammation. In contrast, social support appears to protect against morbidity and mortality, reduce levels of inflammation, and improve PTSD outcomes.MethodsWe examined relationships among social isolation, perceived social support, and inflammation in Veterans Affairs (VA) patients with and without PTSD. Our sample included 735 (35% PTSD+) participants from the Mind Your Heart Study (mean age=58±11; 94% male). Social isolation was assessed with the Berkman Syme Social Network Index; perceived social support with the Multidimensional Scale of Perceived Social Support; and PTSD with the Clinician Administered PTSD Scale. Inflammation was indexed by high sensitivity C-reactive protein, white blood cell count, and fibrinogen. Hierarchical linear regression was used to examine associations between social measures and inflammation. PROCESS was used to examine the interactive effects of social relationships and PTSD on inflammation.ResultsSocial isolation, but not low perceived social support, trended towards an association with elevated inflammation in the full sample. However, considering groups with and without PTSD separately, social isolation was significantly associated with all inflammatory markers among individuals without PTSD, but not among those with PTSD.ConclusionsSocial integration is associated with reduced inflammation in individuals without, but not with, PTSD. Socially integrated individuals with PTSD did not have lower levels of inflammatory markers than socially isolated individuals with PTSD.
Databáze: OpenAIRE
Externí odkaz: