CCDC26 Gene Polymorphism and Glioblastoma Risk in the Han Chinese Population
| Autor: | Xiao-Bing Wei, Yong-Kuan Gong, Chao Chen, Guodong Gao, Tian-Bo Jin, Jiayi Zhang, Tingting Geng, Cui-Ping Chen, Gang Li |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Cancer Research Linkage disequilibrium Genotype Epidemiology Single-nucleotide polymorphism Biology Polymorphism Single Nucleotide Young Adult Asian People Humans SNP Genetic Predisposition to Disease Allele Alleles Aged Genetics Brain Neoplasms Haplotype Intracellular Signaling Peptides and Proteins Public Health Environmental and Occupational Health Case-control study Middle Aged Logistic Models Haplotypes Oncology Case-Control Studies Female RNA Long Noncoding Gene polymorphism Glioblastoma |
| Zdroj: | Asian Pacific Journal of Cancer Prevention. 15:3629-3633 |
| ISSN: | 1513-7368 |
| DOI: | 10.7314/apjcp.2014.15.8.3629 |
| Popis: | Background: Glioblastoma (GBM) is an immunosuppressive tumor whose median survival time is only 1215 months, and patients with GBM have a uniformly poor prognosis. It is known that heredity contributes to formation of glioma, but there are few genetic studies concerning GBM. Materials and Methods: We genotyped six tagging SNPs (tSNP) in Han Chinese GBM and control patients. We used Microsoft Excel and SPSS 16.0 statistical package for statistical analysis and SNP Stats to test for associations between certain tSNPs and risk of GBM in five different models. ORs and 95%CIs were calculated for unconditional logistic-regression analysis with adjustment for age and gender. The SHEsis software platform was applied for analysis of linkage disequilibrium, haplotype construction, and genetic associations at polymorphism loci. Results: We found rs891835 in CCDC26 to be associated with GBM susceptibility at a level of p=0.009. The following genotypes of rs891835 were found to be associated with GBM risk in four different models of gene action: i) genotype GT (OR=2.26; 95%CI, 1.29-3.97; p=0.019) or GG (OR=1.33; 95%CI, 0.23-7.81; p=0.019) in the codominant model; ii) genotypes GT and GG (OR=2.18; 95%CI, 1.26-3.78; p=0.0061) in the dominant model; iii) GT (OR=2.24; 95%CI, 1.28-3.92; p=0.0053) in the overdominant model; iv) the allele G of rs891835 (OR=1.85; 95%CI, 1.14-3.00; p=0.015) in the additive model. In addition, “CG” and “CGGAG” were found by haplotype analysis to be associated with increased GBM risk. In contrast, genotype GG of CCDC26 rs6470745 was associated with decreased GBM risk (OR=0.34; 95%CI, 0.12-1.01; p=0.029) in the recessive model. Conclusions: Our results, combined with those from previous studies, suggest a potential genetic contribution of CCDC26 to GBM progression among Han Chinese. |
| Databáze: | OpenAIRE |
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