Effect of influenza vaccine on tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in older adults
| Autor: | Samah Almed, Marzieh Keshtkarjahromi, Rebeca Rios, Min Ouyang, Jeremy D. Walston, Maryam Keshtkar-Jahromi, Sean X. Leng, Huifen Li |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Influenza vaccine Antigens Differentiation Myelomonocytic Receptors Cell Surface Antibodies Viral Article 03 medical and health sciences Antigens CD Influenza Human Medicine Humans Inducer Cytokine TWEAK Aged Aged 80 and over General Veterinary General Immunology and Microbiology business.industry Vaccination Public Health Environmental and Occupational Health Antibody titer Age Factors Titer 030104 developmental biology Infectious Diseases Apoptosis Influenza Vaccines Immunology Molecular Medicine Tumor necrosis factor alpha Female business Biomarkers |
| Zdroj: | Vaccine. 36(16) |
| ISSN: | 1873-2518 |
| Popis: | Influenza immunization is recommended for older adults annually, and has been reported to have cardiovascular protective effects. TNF-related weak inducer of apoptosis (TWEAK), an inflammatory mediator implicated in the development of cardiovascular diseases, could be a mechanism for such effect. The objective of this study was to evaluate the effect of influenza vaccine on TWEAK levels. Older persons over 70 years of age were recruited during 2007-2008 influenza season and immunized with the standard dose trivalent inactivated influenza vaccine. Frailty was evaluated using a validated set of criteria. Sera were collected immediately before and during the 4th week after vaccination. Pre- and post-vaccination levels of TWEAK, soluble CD163 (sCD163) and strain-specific influenza antibody titers were measured in 69 participants. Multiple regression analyses were employed to examine the effect of influenza vaccine on TWEAK and sCD163, adjusting for age, sex, and hypertension. Post-vaccination TWEAK [mean ± standard deviation (SD) = 591.7 ± 290.1 pg/ml] was significantly lower than pre-vaccination level (690.6 ± 330.0 pg/ml) (p = .003). No significant difference was observed between pre and post-vaccination sCD163 levels (p = .71). Post-vaccination TWEAK levels were significantly higher in men (p = .01) and in participants with college or higher level of education (p = .044). There was no significant difference in post-vaccination TWEAK according to other demographics or pre-existing medical conditions. A 2-fold or greater antibody titer against H1N1 vaccine strain was associated with a more pronounced reduction in TWEAK at the p < .10 level (p = .091). A time by frailty interaction term (p = .091) indicated that the vaccination-induced reduction of TWEAK was greatest among frail individuals. These results of this observational study indicate that the impact of Influenza vaccine on TWEAK, including the role of specific antibody responses of specific vaccine strains and frailty status, warrants further investigation. Such investigation may elucidate whether this effect plays a role in mediating cardiovascular protection of influenza vaccination. |
| Databáze: | OpenAIRE |
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