Shared Immune and Repair Markers During Experimental Toxoplasma Chronic Brain Infection and Schizophrenia
| Autor: | Jakub Tomasik, Robert H. Yolken, Wolfgang Kluge, Vern B. Carruthers, Tracey L. Schultz, Sabine Bahn |
|---|---|
| Přispěvatelé: | Neurosciences |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pathogenesis 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Immune system Medicine Animals Humans Interferon gamma biology business.industry Toxoplasma gondii Brain Regular Article biology.organism_classification medicine.disease Toxoplasmosis Psychiatry and Mental health Chronic infection Disease Models Animal 030104 developmental biology chemistry Schizophrenia Plasminogen activator inhibitor-1 Toxoplasmosis Cerebral Immunology Chronic Disease business Toxoplasma 030217 neurology & neurosurgery Biomarkers medicine.drug |
| Zdroj: | Schizophrenia Bulletin, 42(2), 386-395. Oxford University Press |
| ISSN: | 0586-7614 |
| Popis: | Chronic neurologic infection with Toxoplasma gondii is relatively common in humans and is one of the strongest known risk factors for schizophrenia. Nevertheless, the exact neuropathological mechanisms linking T gondii infection and schizophrenia remain unclear. Here we utilize a mouse model of chronic T gondii infection to identify protein biomarkers that are altered in serum and brain samples at 2 time points during chronic infection. Furthermore, we compare the identified biomarkers to those differing between "postmortem" brain samples from 35 schizophrenia patients and 33 healthy controls. Our findings suggest that T gondii infection causes substantial and widespread immune activation indicative of neural damage and reactive tissue repair in the animal model that partly overlaps with changes observed in the brains of schizophrenia patients. The overlapping changes include increases in C-reactive protein (CRP), interleukin-1 beta (IL-1 beta), interferon gamma (IFN gamma), plasminogen activator inhibitor 1 (PAI-1), tissue inhibitor of metalloproteinases 1 (TIMP-1), and vascular cell adhesion molecule 1 (VCAM-1). Potential roles of these factors in the pathogenesis of schizophrenia and toxoplasmosis are discussed. Identifying a defined set of markers shared within the pathophysiological landscape of these diseases could be a key step towards understanding their specific contributions to pathogenesis. |
| Databáze: | OpenAIRE |
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