Flow Cytometry Characterization of Pluripotent Transmembrane Glycoproteins on Resident Cervix Uteri Cells in Patients Screened for Cervical Cancer

Autor:	Francesco Paolo De Luca, Francesco Cacciatore, Dario Costa, Vincenzo Grimaldi, Schettino Mt, Nicola Colacurci, Gelsomina Mansueto, Pasquale De Franciscis, Claudio Napoli
Přispěvatelé:	Colacurci, N., Schettino, M. T., Grimaldi, V., De Luca, F. P., Mansueto, G., Costa, D., Cacciatore, F., De Franciscis, P., Napoli, C.
Rok vydání:	2020
Předmět:	0301 basic medicine Cancer Research Biopsy Uterine Cervical Neoplasms Cervix Uteri CD38 0302 clinical medicine Prospective Studies Papillomaviridae Cervical cancer Membrane Glycoproteins immunohistochemical analysi medicine.diagnostic_test Integrin beta1 virus diseases CD29 General Medicine Flow Cytometry Immunohistochemistry female genital diseases and pregnancy complications transmembrane glycoprotein medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Neoplastic Stem Cells Female Membrane Glycoprotein Human Adult Cancer stem-like cells (CSCs) cervical intraepithelial neoplasia (CIN) Cervical intraepithelial neoplasia Immunophenotyping Flow cytometry 03 medical and health sciences medicine Humans Cervical Intraepithelial Neoplasia Papillomavirus Infection Cervix Cyclin-Dependent Kinase Inhibitor p16 business.industry Histocompatibility Antigens Class I Papillomavirus Infections Mesenchymal stem cell Histocompatibility Antigens Class II flow cytometry analysi Uterine Cervical Dysplasia medicine.disease ADP-ribosyl Cyclase 1 human papillomavirus (HPV) Prospective Studie 030104 developmental biology Cancer research Neoplastic Stem Cell Neoplasm Grading business
Zdroj:	Cancer Investigation. 38:228-239
ISSN:	1532-4192 0735-7907
Popis:	The aim of this study was to characterize both by flow cytometry analysis and immunohistochemistry cervix uteri cells of nulliparous women screened for cervical intraepithelial neoplasia (CIN) in comparison to a group without CIN by using mesenchymal stem cell-like and hematopoietic lineage markers. A significant expression for CD29, CD38, HLA-I, and HLA-II was correlated positively to the CIN degree and it was more relevant in patients positive for human papilloma virus (HPV). Thus, identification and detailed characterization of pluripotent resident in uteri cells could be a promising therapeutic target.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eb1698de397702933b354a5bc50eaa4 https://doi.org/10.1080/07357907.2020.1742349 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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