Two cases of fatal intoxication due to tranylcypromine overdose
| Autor: | Peter J. Boniface |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Detection limit
Male Chemical Health and Safety Chromatography Chromatography Gas Chemistry Tranylcypromine overdose Health Toxicology and Mutagenesis Tranylcypromine Poison control Urine Middle Aged Toxicology Analytical Chemistry chemistry.chemical_compound Liver medicine Environmental Chemistry Ingestion Humans Gas chromatography Trifluoroacetic anhydride Drug Overdose medicine.drug |
| Zdroj: | Journal of analytical toxicology. 15(1) |
| ISSN: | 0146-4760 |
| Popis: | Two cases of death following the ingestion of tranylcypromine are presented. High concentrations of tranylcypromine wel'e determined in blood, urine, and liver by gas-liquid chromatography. Tranylcypromine was extracted from buffered blood with n-butyl chloride. The evaporated extract was derlvatized with trifluoroacetic anhydride and analyzed by gas chromatography with nitrogen-phosphorus selective detection. The method was linear in blood over the range 0.5-20 mg/L with a limit of quantitation of about 0.2 mg/L. |
| Databáze: | OpenAIRE |
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