Staphylococcal Enterotoxin B Affects in vitro IgE Synthesis, Interferon-γ, lnterleukin-4 and lnterleukin-5 Production in Atopic Eczema
| Autor: | K Neuber, K Steinrücke, Johannes Ring |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Staphylococcus aureus
Immunology Eczema chemical and pharmacologic phenomena Enterotoxin Lymphocyte Activation Immunoglobulin E Dermatitis Atopic Enterotoxins Interferon-gamma Th2 Cells Eosinophil activation medicine Superantigen Humans Immunology and Allergy Interferon gamma Interleukin 5 Cells Cultured Interleukin 4 Antigens Bacterial Superantigens biology business.industry Interleukin hemic and immune systems General Medicine Culture Media Conditioned biology.protein Interleukin-4 Interleukin-5 business medicine.drug |
| Zdroj: | International Archives of Allergy and Immunology. 107:179-182 |
| ISSN: | 1423-0097 1018-2438 |
| Popis: | Peripheral blood mononuclear cells from patients with atopic eczema (AE) stimulated with the 'superantigen' Staphylococcus enterotoxin B (SEB) secreted significantly more interleukin (IL)-4 and IL-5 as well as IgE, and markedly less interferon-gamma than those from healthy controls. Our results support the assumption that SEB produced by S. aureus colonizing the skin of patients with AE may induce expansion of IL-4- and IL-5-producing Th2 clones, leading to increased IgE synthesis and eosinophil activation. |
| Databáze: | OpenAIRE |
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