Identification of a novel GRIN2D variant in a neonate with intractable epileptic encephalopathy-a case report
| Autor: | Yudong Zhang, Li Ma, Li Li, Junchen Fang, Chao Jia, Min Sun, Jiancheng Jiao, Lingzhi Meng |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Receptors N-Methyl-D-Aspartate NMDA receptors 03 medical and health sciences Epilepsy 0302 clinical medicine Seizures 030225 pediatrics medicine Humans case report 030212 general & internal medicine anti-epileptic medications Brain Diseases business.industry Infant Newborn lcsh:RJ1-570 Apnea Electroencephalography lcsh:Pediatrics medicine.disease Clonazepam Hypsarrhythmia de novo mutation GRIN2D variants epileptic encephalopathy Mutation Pediatrics Perinatology and Child Health Midazolam Hypertonia Phenobarbital Levetiracetam medicine.symptom business Spasms Infantile medicine.drug |
| Zdroj: | BMC Pediatrics, Vol 21, Iss 1, Pp 1-4 (2021) BMC Pediatrics |
| ISSN: | 1471-2431 |
| Popis: | Background N-methyl-D-aspartate (NMDA) receptors are ligand-gated ion channels that mediate excitatory synaptic transmission in the central nervous system. The functional NMDA receptors are heterotetramers consisting mainly of two GluN1 and two GluN2 subunits. GluN2 is encoded by the GRIN2D gene. A few case series have shown that GRIN2D variants are linked to developmental and epileptic encephalopathy. In this article, we report a novel GRIN2D variant, namely c.2021C > A (p.T674K) in a neonate with intractable epileptic encephalopathy. Case presentation A 12-day-old boy who had stiffness of the lower and upper extremities since birth was transferred from a local hospital to our department. On admission, the patient presented with head tilting backwards, staring, apnea and hypertonia of limbs. Video electroencephalogram showed continuous, generalized or multi-focal spike-wave and spike-and-slow wave discharges and hypsarrhythmia. A treatment regimen composed of phenobarbital, midazolam, levetiracetam and clonazepam was administered, which however led to only partial control of the seizure. Whole-exome sequencing identified c.2021C > A (p.T674K) in GRIN2D in the patient while such a mutation was not detected in the parents. The patient was hospitalized for 1 month and died of sudden cardio-respiratory arrest 2 weeks after discharge. Conclusions A novel variant of GRIN2D was identified in a neonate with epileptic encephalopathy. Epilepsy associated with this GRIN2D mutation is refractory to conventional anti-epileptic medications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink