Gastric-Mucous Membrane Protection Activity of Coptisine Derivatives
| Autor: | Eriko Osawa, Yumiko Yamaoka, Toshio Yokoi, Hiroyuki Hirano |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
Coptisine Coptis chinensis Berberine Pharmaceutical Science Plant Roots Chemical synthesis Structure-Activity Relationship chemistry.chemical_compound medicine Animals Structure–activity relationship Rats Wistar Isoquinoline Pharmacology Catechol Ethanol General Medicine Rats Sucralfate Membrane chemistry Biochemistry Gastric Mucosa Drugs Chinese Herbal medicine.drug |
| Zdroj: | Biological and Pharmaceutical Bulletin. 24:1277-1281 |
| ISSN: | 1347-5215 0918-6158 |
| DOI: | 10.1248/bpb.24.1277 |
| Popis: | Coptisine and 8-oxocoptisine were isolated as principles of the gastric-mucous membrane protection from Coptidis rhizoma. The two compounds showed stronger activity than cimetidine and sucralfate. We prepared several derivatives having a partial structure of coptisine from commercially available starting materials. The compounds obtained were tested for gastric-mucous membrane protective activity and a correlation between activity and structure was studied. Our results suggest that the partial charge of the catechol skeleton is related to activity. |
| Databáze: | OpenAIRE |
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