Fish oil supplementation enhanced CPT-11 (irinotecan) efficacy against MCF7 breast carcinoma xenografts and ameliorated intestinal side-effects
| Autor: | W. E. Hardman, M P Moyer, Ivan L. Cameron |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Cancer Research
endocrine system diseases Gastrointestinal Diseases medicine.medical_treatment Apoptosis Pharmacology fish oil Mice Intestinal mucosa CPT-11 Tumor Cells Cultured heterocyclic compounds intestinal side-effects Regular Article Drug Synergism Fish oil Oncology Female medicine.drug endocrine system medicine.medical_specialty Colon Duodenum Diet therapy Transplantation Heterologous Mice Nude Antineoplastic Agents Breast Neoplasms Adenocarcinoma Biology Irinotecan Thiobarbituric Acid Reactive Substances breast cancer Fish Oils Internal medicine medicine Carcinoma Animals Humans neoplasms Chemotherapy Muscle Smooth medicine.disease digestive system diseases Endocrinology Camptothecin Corn Oil Lipid Peroxidation Corn oil |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/sj.bjc.6690713 |
| Popis: | The cancer chemotherapeutic efficacy of the topoisomerase I inhibitor, CPT-11 (irinotecan) is often limited by the induction of severe delayed diarrhoea. In animal studies, CPT-11 use is associated with histopathological damage to the mucosa of the small and large intestines. Results from the present study demonstrate that 60 mg CPT-11 per kg body weight (i.v. q4d × 6) halted the growth, but did not cause significant regression, of MCF7 human breast carcinoma xenografts in mice fed a diet containing 7% corn oil. However, when the diet of the MCF7-bearing mice was supplemented with 3% or 6% fish oil, the same CPT-11 treatment caused significant regression of the MCF7 xenograft. Histomorphometric analyses of intestinal mucosa of mice treated with CPT-11 and fed the diet containing 7% corn oil indicated that treatment with CPT-11 induced structural changes in the intestinal mucosa which persisted at least 5 days after the last dose of CPT-11. The intestinal mucosal architecture of mice that were treated with CPT-11 and fed the diets containing fish oil was largely unchanged from the architecture of the group of mice which did not receive CPT-11. These findings indicate that fish oil supplements may be a useful adjunct to CPT-11 treatment. © 1999 Cancer Research Campaign |
| Databáze: | OpenAIRE |
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