The effect of bovine milk lactoferrin on human breast cancer cell lines
| Autor: | Lígia R. Rodrigues, D. C. Duarte, José A. Teixeira, Ana Nicolau |
|---|---|
| Přispěvatelé: | Universidade do Minho |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Cell Survival
apoptosis and migration Antineoplastic Agents Apoptosis Breast Neoplasms 03 medical and health sciences 0302 clinical medicine Immune system Breast cancer Cell Movement Cell Line Tumor Genetics medicine Animals Humans Viability assay skin and connective tissue diseases 030304 developmental biology Cell Proliferation 0303 health sciences biology Lactoferrin Cancer Cell migration Biological activity medicine.disease Viability and proliferation 3. Good health Milk Biochemistry Cell culture 030220 oncology & carcinogenesis biology.protein Cancer research Animal Science and Zoology Cattle Female Drug Screening Assays Antitumor Food Science |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| Popis: | The evidence that biologically active food components are key environmental factors affecting the incidence of many chronic diseases is overwhelming. However, the full extent of such components in our diet is unknown, as well as our understanding of their mechanisms of action. Beyond their interaction with the gut and intestinal immune functions, more benefits are being tested for whey proteins such as lactoferrin, namely as anti-cancer agents. Lactoferrin is an iron-binding protein that has been reported to inhibit several types of cancer. In the present work, the effects of bovine milk lactoferrin on human breast cancer HS578T and T47D cells were studied. The cells were either untreated or submitted to lactoferrin concentrations ranging from 0. 125 to 125 μM. Lactoferrin decreased 47% and 54% the cell viability of HS578T and T47D, respectively, and increased apoptosis about twofold for both cell lines. Proliferation rates decreased between 40.3 and 63.9% for HS578T and T47D, respectively. T47D cell migration decreased in the presence of the protein. Although the mechanisms of action have still not been unrevealed, the results gathered in this work suggest that lactoferrin interferes with some of the most important steps involved in cancer development. (undefined) |
| Databáze: | OpenAIRE |
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