Molecular pathways and therapeutic targets in lung cancer
Autor: | Gregory A. Otterson, George R. Simon, Phillip A. Dennis, Ravi Salgia, Emma Shtivelman, Thomas A. Hensing, Raphael Bueno |
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Rok vydání: | 2014 |
Předmět: |
Oncology
medicine.medical_specialty medicine.medical_treatment Antineoplastic Agents Review Treatment of lung cancer Small-cell carcinoma Targeted therapy immune therapy Neoplasms Internal medicine Animals Humans Medicine Molecular Targeted Therapy Lung cancer business.industry respiratory system targeted therapy medicine.disease Neoplasm Proteins Immune therapy Clinical trial lung cancer Molecular targets Adenocarcinoma business Signal Transduction |
Zdroj: | Oncotarget |
ISSN: | 1949-2553 |
Popis: | Lung cancer is still the leading cause of cancer death worldwide. Both histologically and molecularly lung cancer is heterogeneous. This review summarizes the current knowledge of the pathways involved in the various types of lung cancer with an emphasis on the clinical implications of the increasing number of actionable molecular targets. It describes the major pathways and molecular alterations implicated in the development and progression of non-small cell lung cancer (adenocarcinoma and squamous cancer), and of small cell carcinoma, emphasizing the molecular alterations comprising the specific blueprints in each group. The approved and investigational targeted therapies as well as the immune therapies, and clinical trials exploring the variety of targeted approaches to treatment of lung cancer are the main focus of this review. |
Databáze: | OpenAIRE |
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