Cerebrospinal Fluid Lysozyme in Bacterial and Viral Meningitis
| Autor: | Sakari Reitamo, Teddy Weber, Yrjö Kerttula, Matti Klockars |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Microbiological culture
medicine.drug_class Microgram Antibiotics Echovirus Infections 02 engineering and technology Meningitis Meningococcal 01 natural sciences Diagnosis Differential chemistry.chemical_compound Cerebrospinal fluid Internal Medicine Viral meningitis Humans Medicine Mumps CSF albumin L-Lactate Dehydrogenase Meningitis Pneumococcal business.industry 010401 analytical chemistry 021001 nanoscience & nanotechnology medicine.disease Meningitis Viral 3. Good health 0104 chemical sciences chemistry Immunology Muramidase Lysozyme 0210 nano-technology business Meningitis |
| Zdroj: | Acta Medica Scandinavica. 203:71-74 |
| ISSN: | 0001-6101 |
| DOI: | 10.1111/j.0954-6820.1978.tb14834.x |
| Popis: | The concentration of lysozyme (LZM) in cerebrospinal fluid was determined in 25 patients with bacterial meningitis, in 18 patients with viral meningitis and in 25 control patients who had other fibrile illnesses. The concentration of LZM was less than 1.5 microgram/ml in all control patients, and slightly to markedly raised in 10 patients with viral meningitis and in 11 out of 13 patients with untreated bacterial meningitis. The concentration of LZM was significantly different in the viral and bacterial meningitis patients (p less than 0.001). Most raised concentrations of cerebrospinal fluid LZM persisted for at least one week after the start of antibiotic treatment. The concentrations of LZM correlated well with concentrations of lactic dehydrogenase. These results show that the determination of cerebrospinal fluid LZM is a useful tool in the differential diagnosis of meningitis, particularly when the prehospital treatment with antibiotics may be responsible for a diagnostically misleading negative bacterial culture of the cerebrospinal fluid and altered cerebrospinal fluid cytology. |
| Databáze: | OpenAIRE |
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