Metiamide in the Zollinger-Ellison syndrome
| Autor: | J D Reed, D. J. Sanders, E R Grund, I. T. Miller, Venables Cw, E L Blair, M. H. Thompson |
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| Rok vydání: | 1975 |
| Předmět: |
Adult
Male Drug Ulcer healing medicine.medical_specialty Physiology media_common.quotation_subject Remission Spontaneous Metiamide Zollinger-Ellison Syndrome chemistry.chemical_compound Internal medicine Gastrins medicine Humans media_common Clinical Trials as Topic Gastric Juice business.industry Thiourea Gastroenterology Antagonist General Medicine Middle Aged Hepatology medicine.disease digestive system diseases Zollinger-Ellison syndrome Gastric secretion Endocrinology chemistry Drug Evaluation Female business Histamine medicine.drug |
| Zdroj: | The American Journal of Digestive Diseases. 20:1123-1130 |
| ISSN: | 1573-2568 0002-9211 |
| DOI: | 10.1007/bf01070755 |
| Popis: | The histamine H2-receptor antagonist metiamide is an inhibitor of endogenous and stimulated gastric-acid secretion. It appears to have therapeutic possibilities in duodenal-ulcer disease. Three patients exhibiting the Zollinger-Ellison syndrome have been treated with this drug for six months or more. Rapid symptomatic improvement occurred in each case, followed by ulcer healing. There were also reductions in gastric secretion and consistent changes in the fasting serum-gastrin concentration. One patient relapsed temporarily during therapy. There have been no side effects. It is concluded that, in the short term, metiamide is of benefit in the Zollinger-Ellison syndrome. |
| Databáze: | OpenAIRE |
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