A comparative assessment of biological effects and chemical profile of Italian asphodeline lutea extracts

Autor: Luigi Menghini, Clinio Locatelli, Lidia Leporini, Dora Melucci, Cristina Campestre, Alessandro Zappi, Simone Carradori, Gokhan Zengin, Francesco De Laurentiis, Carene Marie Nancy Picot, Marcello Locatelli, Mohamad Fawzi Mahomoodally
Přispěvatelé: Selçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümü, Zengin, Gökhan, Melucci, Dora, Locatelli, Marcello, Locatelli, Clinio, Zappi, Alessandro, De Laurentiis, Francesco, Carradori, Simone, Campestre, Cristina, Leporini, Lidia, Zengin, Gokhan, Picot, Carene Marie Nancy, Menghini, Luigi, Mahomoodally, Mohamad Fawzi
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Antioxidant
Tyrosinase
medicine.medical_treatment
Pharmaceutical Science
Anthraquinones
Diabete
Neurodegenerative disease
01 natural sciences
Anthraquinone
Plant Roots
Antioxidants
Analytical Chemistry
chemistry.chemical_compound
Drug Discovery
Bioassay
Food science
Chromatography
High Pressure Liquid
Cadmium
biology
Monophenol Monooxygenase
Diabetes
Heavy metal
Italy
Heavy metals
Chemistry (miscellaneous)
Acetylcholinesterase
Molecular Medicine
Composition (visual arts)
Asphodeline lutea
Asphodelaceae
chemistry.chemical_element
Zinc
Flowers
HPLC-PDA
heavy metals
tyrosinase
diabetes
neurodegenerative disease
Article
lcsh:QD241-441
lcsh:Organic chemistry
Phenols
medicine
Humans
Physical and Theoretical Chemistry
010405 organic chemistry
Plant Extracts
Organic Chemistry
biology.organism_classification
0104 chemical sciences
010404 medicinal & biomolecular chemistry
chemistry
Cholinesterase Inhibitors
alpha-Amylases
Zdroj: Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules; Volume 23; Issue 2; Pages: 461
Molecules, Vol 23, Iss 2, p 461 (2018)
Popis: WOS: 000426436300241
PubMed: 29463056
The present study aims to highlight the therapeutic potential of Asphodeline lutea (AL), a wild edible plant of the Mediterranean diet. Roots, aerial parts, and flowers of AL at two different phenological stages were collected from three locations in Italy. The inhibitory activities of extracts on strategic enzymes linked to human diseases were assessed. The antioxidant properties were evaluated in vitro, using six standard bioassays. The phenolic and anthraquinone profiles were also established using HPLC-PDA. Zinc, cadmium, lead, and copper contents were also determined. All the samples inhibited acetylcholinesterase (from 1.51 to 2.20 mg GALAEs/g extract), tyrosinase (from 7.50 to 25.3 mg KAEs/g extract), and alpha-amylase (from 0.37 to 0.51 mmol ACAEs/g extract). Aloe-emodin and physcion were present in all parts, while rhein was not detected. The phenolic profile and the heavy metals composition of specimens gathered from three different regions of Italy were different. It can be argued that samples collected near the street can contain higher concentrations of heavy metals. The experimental data confirm that the A. lutea species could be considered as a potential source of bioactive metabolites, and its consumption could play a positive and safe role in human health maintenance.
Italian Ministry of University (FAR)
This work was supported by grants from the Italian Ministry of University (FAR 2016). The research is part of the project "Filiera delle piante officinali in Abruzzo".
Databáze: OpenAIRE
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