Human disorders associated with inflammation and the evolving role of natural products to overcome
| Autor: | Karuna Shanker, Pradeep Kumar, Akhilesh K. Verma, Navneet Kishore |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Normal tissue
Inflammation Bioinformatics Skin Diseases 01 natural sciences Proinflammatory cytokine Arthritis Rheumatoid Pathogenesis 03 medical and health sciences Health problems Molecular level Immune system Neoplasms Drug Discovery medicine Humans 030304 developmental biology Pharmacology Biological Products 0303 health sciences 010405 organic chemistry Chemistry Anti-Inflammatory Agents Non-Steroidal Organic Chemistry General Medicine 0104 chemical sciences Cardiovascular Diseases Molecular targets medicine.symptom |
| Zdroj: | European Journal of Medicinal Chemistry. 179:272-309 |
| ISSN: | 0223-5234 |
| Popis: | Inflammation is a biological function which triggered after the mechanical tissue disruption or from the responses by the incidence of physical, chemical or biological negotiator in body. These responses are essential act provided by the immune system during infection and tissue injury to maintain normal tissue homeostasis. Inflammation is a quite complicated process at molecular level with the involvement of several proinflammatory expressions. Several health problems are associated with prolonged inflammation, which effects nearly all major to minor diseases. The molecular and epidemiological studies jagged that the inflammation is closely associated with several disorders with their specific targets. It would be great achievement for human health around the world to overcome on inflammation. Mostly used anti-inflammatory drugs are at high risk of side effects and also expensive. Hence, the plant-based formulations gained a wide acceptance by the public and medical experts to treat it. Due to extensive dispersal, chemical diversity and systematically established biological potentials of natural products have induced renewed awareness as a gifted source for medications. However, today's urgent need to search for cheaper, more potent and safe anti-inflammatory medications to overcome on current situation. The goal of this review to compile an update on inflammation, associated diseases, molecular targets, inflammatory mediators and role of natural products. The entire text concise the involvement of various cytokines in pathogenesis of various human disorders. This assignment discussed about 321 natural products with their promising anti-inflammatory potential discovered during January 2009 to December 2018 with 262 citations. |
| Databáze: | OpenAIRE |
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