Demographic and Clinical Characteristics Associated With Severity, Clinical Outcomes, and Mortality of COVID-19 Infection in Gabon

Autor: Avelin Fobang Aghokeng, Pascal Pineau, Berthe Amélie Iroungou, Laurette Guignali Mangouka, Farrel Nzigou Boucka, Jean Raymond Nzenze, Pamela Moussavou-Boundzanga, Berthold Bivigou-Mboumba, Judicaël Obame-Nkoghe, Romain Tchoua, Augustin Mouinga-Ondémé
Přispěvatelé: Centre International de Recherches Médicales de Franceville (CIRMF), Service de Médecine Interne, Hôpital d'Instruction des Armées Omar Bongo Ondimba, Université des Sciences et Techniques de Masuku [Franceville, Gabon] (USTM), Agence Gabonaise d'Etudes et d'Observations Spatiales, Génétique et évolution des maladies infectieuses (GEMI), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Service de Réanimation, Hôpital d'Instruction des Armées Omar Bongo Ondimba, Organisation Nucléaire et Oncogenèse / Nuclear Organization and Oncogenesis, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), This work was supported by the Gabonese government (Prof Tchoua and Prof Nzenze)., We are grateful to all patients involved in this study. We also acknowledge Remi Charlebois, MS (GSSHealth), for attentive review of the manuscript. He was not paid for this contribution., Pineau, Pascal, Université des Sciences et Techniques de Masuku (USTM), Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC)
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Adult
Male
Pediatrics
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19)
Cross-sectional study
Central china
Severity of Illness Index
Risk Factors
Interquartile range
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Diabetes mellitus
Severity of illness
parasitic diseases
Diabetes Mellitus
Medicine
Humans
Gabon
Risk factor
Pandemics
Developing Countries
Demography
Original Investigation
[SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases
[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases
business.industry
SARS-CoV-2
Mortality rate
Research
Age Factors
COVID-19
General Medicine
Middle Aged
medicine.disease
Online Only
Cross-Sectional Studies
Infectious Diseases
Africa
[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Female
business
Zdroj: JAMA Network Open
JAMA Network Open, 2021, 4 (9), pp.e2124190
ISSN: 2574-3805
Popis: This cross-sectional study describes the clinical characteristics and outcomes of patients with COVID-19 infection in Gabon from March to June 2020.
Key Points Question What were the epidemiologic and clinical aspects of patients with COVID-19 infection in the Armed Forces Hospital in Libreville, Gabon, from March to June 2020? Findings In this cross-sectional study of 837 patients with COVID-19 in Gabon, 63% had no symptoms. Severity of disease and mortality were associated with advanced age and advanced stage of lung damage. Meaning Findings from this observational study provide preliminary data for use in future epidemiologic studies of COVID-19 in Gabon.
Importance Since the emergence of COVID-19 in central China, sub-Saharan African countries, with the exception of South Africa, have been relatively spared during the COVID-19 pandemic. Consequently, few descriptive studies from this region are available. Objective To describe the clinical characteristics and outcomes of patients with COVID-19 infection in Gabon, from March to June 2020. Design, Setting, and Participants A single-center, cross-sectional study of 837 patients with COVID-19 was conducted from March to June 2020 in the Armed Forces Hospital in Libreville, Gabon. Main Outcomes and Measures Demographic and clinical characteristics and imaging findings of hospitalized patients with COVID-19. Results Of the 837 patients enrolled, 572 (68.3%) were men, and 264 (31.5%) were women (male to female ratio, 2:1); the median (interquartile range [IQR]) age was 35 (30-45) years (mean [SD] age, 38.0 [12.2] years. The mortality rate associated with COVID-19 was low (1.4%). Of these 837 patients, 524 (62.6%) were categorized as having no symptoms, 282 (33.7%) as having mild symptoms, and 31 (3.7%) as having severe symptoms. Patients with severe symptoms were older (mean [SD] age, 46.1 [14.7] years) than patients with mild symptoms (mean [SD] age, 41.3 [12.5] years) and those with no symptoms (mean [SD] age, 35.7 [11.3] years) (Kruskal-Wallis χ22 = 53.5; P
Databáze: OpenAIRE
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