Formulation & In vivo Evaluation of Self Nano Emulsifying Drug Delivery System of Doravirine
| Autor: | Komala Devender Reddy, Pamu Sandhya |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| DOI: | 10.5281/zenodo.7240711 |
| Popis: | The study is an attempt to improve the solubility and bioavailability of doravirine by employing selfnanoemulsifying drug delivery technique (SNEDDS). Based on the components' effectiveness at solubilizing and emulsifying one another, preliminary screening was done to choose the oil, surfactant, and co-surfactant. The region of nanoemulsification was found using pseudo ternary phase diagrams. In terms of globule size, globule size distribution, zeta potential, and surface shape of the resulting nanoemulsions, the created self-nanoemulsifying drug delivery systems (SNEDDS) were assessed. The optimized SNEDDS formulation (F8) contained drug (100 mg), neobee M5 (22.2%), caproic acid (58.2%) and PEG 600 (19.4%). The SNEDDS was further evaluated for its turbidity, robustness, entrapment efficiency, % drug content, droplet size and zeta potential. The optimized formulation of drug-loaded SNEDDS exhibited 98% entrapment efficiency, 99% drug content and 99% in vitro drug release in 60 min as compared with the plain drug, which had a limited dissolution rate (31%). The particle size for the optimized formulation of SNEDDS (F8) was found to be 67.8 nm with PDI 0.173.In vitro drug release from SNEDDS was significantly higher (p < 0.005) than pure drug. Furthermore, area under the drug concentration time-curve of drug from SNEDDS formulation revealed a significant increase (p < 0.005) in Doravirine absorption compared to pure drug alone. The increase in drug release and bioavailability as compared to drug suspension from SNEDDS formulation may be attributed to the nanosized droplets and enhanced solubility of drug in the SNEDDS. IJSRED - International Journal of Scientific Research and Engineering Development |
| Databáze: | OpenAIRE |
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