Dextrin Nanocomposites as Matrices for Solid Dosage Forms
| Autor: | Hester Oosthuizen, Maria T. Atanasova, Naushad M. Emmambux, Justin Phillips, James Wesley-Smith, Walter Wilhelm Focke, Jaco-Louis Venter, Elizabeth L. du Toit |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Glycerol
Materials science Hot Temperature Retrogradation (starch) Nanofibers Dosage form Nanocomposites chemistry.chemical_compound Crystallinity X-Ray Diffraction Plasticizers Tensile Strength Dextrins Hydroxides General Materials Science Cellulose Acaricides chemistry.chemical_classification Nanocomposite Water Starch chemistry Chemical engineering Hydroxide Stearic acid Dextrin |
| Zdroj: | ACS applied materialsinterfaces. 12(14) |
| ISSN: | 1944-8252 |
| Popis: | Safe application of water-insoluble acaricides requires fast release from solid dosage systems into aquatic environments. Dextrin is a water-soluble form of partially hydrolyzed starch, which may be used as matrix material for these systems if retrogradation can be inhibited by the inclusion of nanofillers. Several glycerol-plasticized thermoplastic dextrin-based nanocomposites were prepared with a twin-screw extrusion-compounding process. The nanofillers included a layered double hydroxide (LDH), cellulose nanofibers (CNF), and stearic acid. The time-dependent retrogradation of the compounds was monitored by X-ray diffraction (XRD) and dynamic mechanical thermal analysis (DMA). XRD showed that composite samples that included stearic acid in the formulation led to the formation of an amylose-lipid complex and a stable crystallinity during aging. The most promising nanocomposite included both stearic acid and CNF. It was selected as the carrier material for the water-insoluble acaricide Amitraz. Fast release rates were observed for composites containing 5, 10, and 20% (w/w) of the pesticide. A significant reduction in the particle size of the released Amitraz powder was observed, which is ascribed to the high-temperature compounding procedure. |
| Databáze: | OpenAIRE |
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