Protective effects of pioglitazone and/or liraglutide on pancreatic β-cells in db/db mice: Comparison of their effects between in an early and advanced stage of diabetes
| Autor: | Sumiko Hamamoto, Tomohiko Kimura, Hideaki Kaneto, Kazuhito Tawaramoto, Hidenori Hirukawa, Kohei Kaku, Mitsuru Hashiramoto, Masashi Shimoda, Seizo Okauchi, Kenji Kohara |
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| Rok vydání: | 2014 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Time Factors medicine.medical_treatment Gene Expression Apoptosis Mice Transgenic Biochemistry Mice Endocrinology Glucagon-Like Peptide 1 Diabetes mellitus Internal medicine Insulin-Secreting Cells medicine RNA Ribosomal 18S Animals Hypoglycemic Agents Insulin Stage (cooking) Molecular Biology Triglycerides Cell Proliferation Pioglitazone Liraglutide business.industry Advanced stage Organ Size medicine.disease Glucagon Disease Models Animal Ki-67 Antigen Diabetes Mellitus Type 2 Proto-Oncogene Proteins c-bcl-2 Concomitant Caspases Disease Progression Thiazolidinediones business medicine.drug |
| Zdroj: | Molecular and cellular endocrinology. 400 |
| ISSN: | 1872-8057 |
| Popis: | The aim was to compare the protective effects of pioglitazone (PIO) and/or liraglutide (LIRA) on β-cells with the progression of diabetes. Male db/db mice were treated with PIO and/or LIRA for 2 weeks in an early and advanced stage. In an early stage insulin biosynthesis and secretion were markedly increased by PIO and LIRA which was not observed in an advanced stage. In concomitant with such phenomena, expression levels of various β-cell-related factors were up-regulated by PIO and LIRA only in an early stage. Furthermore, β-cell mass was also increased by the treatment only in an early stage. Although there was no difference in apoptosis ratio between the two stages, β-cell proliferation was augmented by the treatment only in an early stage. In conclusion, protective effects of pioglitazone and/or liraglutide on β-cells were more powerful in an early stage of diabetes compared to an advanced stage. |
| Databáze: | OpenAIRE |
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