Immunomodulation of acute experimental spinal cord injury with human immunoglobulin G
| Autor: | Ozerk Okutan, Mustafa F. Sargon, Daniel M. Sciubba, Selcuk Palaoglu, Hüsamettin Erdamar, Beril Gok, Etem Beskonakli |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Pathology medicine.medical_specialty Time Factors Severity of Illness Index Neuroprotection Immunoglobulin G Lipid peroxidation chemistry.chemical_compound Physiology (medical) Animals Immunologic Factors Medicine Rats Wistar Spinal cord injury Myelin Sheath Spinal Cord Injuries Peroxidase Neurologic Examination Neurons Behavior Animal biology business.industry General Medicine medicine.disease Spinal cord Rats Disease Models Animal medicine.anatomical_structure Neurology chemistry Myeloperoxidase Microscopy Electron Scanning biology.protein Surgery Lipid Peroxidation Neurology (clinical) Immunomodulation Therapy Antibody business Psychomotor Performance |
| Zdroj: | Journal of Clinical Neuroscience. 16:549-553 |
| ISSN: | 0967-5868 |
| Popis: | Immunomodulation of acute spinal cord injury may inhibit the activity of specific inflammatory cascades and result in recovery of motor function. In this study, evaluation of the protective effect of a well-known anti-inflammatory immunomodulator, immunoglobulin G (IgG), was conducted in rats after a 50 g/cm contusion spinal cord injury. Following injury, 400 mg/kg of IgG was administered to the treatment group. Twenty-four hours later, animals were assessed functionally via an inclined plane and the Basso-Beattie-Bresnahan motor scale and compared to controls. Tissue was reviewed for myeloperoxidase activiy (MPO) and lipid peroxidation (LPO), and electron microscopy was conducted to assess tissue ultrastructure. Significant functional preservation was observed in the IgG treatment group. In addition, biochemical assays revealed decreased MPO activity, and electron microscopic views of tissue showed preserved ultrastructure. IgG treatment following acute contusion injury to the rat spinal cord confers functional and structural neuroprotection. |
| Databáze: | OpenAIRE |
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