The prevalence of anti-hepatitis C antibody among acute febrile illness cases in Idar Taluk, Gujarat, West India

Autor: Dodia Hiren, Varamballi Prasad, Shekara Nikitha, Santhosha Devadiga, Sushama Aswathyraj, Sudandiradas Robin, Govindakarnavar Arunkumar, Jayaram Anup, Sasidharanpillai Sabeena
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Male
Veterinary medicine
anti-hepatitis c antibody
lcsh:QR1-502
Hepacivirus
medicine.disease_cause
lcsh:Microbiology
0302 clinical medicine
Immunology and Microbiology (miscellaneous)
Seroepidemiologic Studies
Epidemiology
Genotype
Prevalence
Immunology and Allergy
Public Health Surveillance
030212 general & internal medicine
Child
Phylogeny
biology
seroprevalence
Hepatitis C
Middle Aged
Infectious Diseases
Child
Preschool
RNA
Viral
Female
Antibody
Microbiology (medical)
Adult
medicine.medical_specialty
Adolescent
Hepatitis C virus
030106 microbiology
Immunology
India
Microbiology
03 medical and health sciences
Young Adult
medicine
Seroprevalence
Humans
Survival rate
Aged
Hepatitis B virus
west india
General Immunology and Microbiology
business.industry
Infant
Hepatitis C Antibodies
hepatitis c virus
medicine.disease
Cross-Sectional Studies
biology.protein
business
Zdroj: Indian Journal of Medical Microbiology, Vol 37, Iss 2, Pp 225-229 (2019)
ISSN: 1998-3646
0255-0857
Popis: Purpose: The major cause of chronic hepatitis is infections with hepatitis B virus and hepatitis C virus (HCV) globally. However, there exists sparse epidemiological data regarding the prevalence of HCV infection from India. Methodology: We carried out a cross-sectional study to estimate the prevalence of anti-HCV antibody among acute febrile illness cases aged between 1 and 65 years in Idar Taluk, Sabarkantha district, Gujarat state located in West India. A total of 702 serum samples collected from the study area during the year 2017, were screened for anti-hepatitis C IgG by enzyme-linked immunosorbent assay. The serum samples screened positive were then subjected to molecular testing for confirmation. Results: Among the 702 study participants screened, 16 cases were reported to be anti-HCV IgG positive with an estimated seroprevalence rate of 2.3% (95% confidence interval: 1.4%–3.7%). Out of the 16 cases, two samples were confirmed positive by molecular testing indicating active infection. When analysed phylogenetically, one strain was genotyped as HCV1b genotype, and the other one was clustered along with HCV3a genotype. Both the patients with hepatitis C infection were observed to be having a probable 1-year survival rate of 100% and a 2-year survival rate of 85% when the Child-Turcotte-Pugh classification was applied. Conclusion: The estimated seroprevalence of hepatitis C in Idar Taluk, Sabarkantha district, west India was 2.3%. HCV genotypes 1b and 3a were observed to be circulating in the study area.
Databáze: OpenAIRE
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