A transgenic rat expressing human APP with the Swedish Alzheimer's disease mutation
| Autor: | Ursula Ganten, Nenad Bogdanovic, Ewa Kloskowska, Elena Popova, Bengt Winblad, Detlev Ganten, Eirikur Benedikz, Michael Bader, Ronnie Folkesson, Tatjana Nilsson, Katarzyna Malkiewicz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Genetically modified mouse
medicine.medical_specialty Amyloid Transgene BACE1-AS Biophysics Hippocampus tau Proteins Biology Biochemistry Presenilin Animals Genetically Modified Alzheimer Disease Internal medicine Cerebellum mental disorders medicine Amyloid precursor protein Presenilin-1 Animals Humans Molecular Biology Cerebral Cortex Sweden Brain Cell Biology medicine.disease Rats Endocrinology Genetic Techniques Mutation biology.protein Alzheimer's disease |
| Zdroj: | Folkesson, R, Malkiewicz, K, Kloskowska, E, Nilsson, T, Popova, E, Bogdanovic, N, Ganten, U, Ganten, D, Bader, M, Winblad, B & Benedikz, E 2007, ' A transgenic rat expressing human APP with the Swedish Alzheimer's disease mutation ', Biochemical and Biophysical Research Communications, vol. 358, no. 3, pp. 777-82 . https://doi.org/10.1016/j.bbrc.2007.04.195 |
| Popis: | In recent years, transgenic mice have become valuable tools for studying mechanisms of Alzheimer's disease (AD). With the aim of developing an animal model better for memory and neurobehavioural testing, we have generated a transgenic rat model of AD. These animals express human amyloid precursor protein (APP) containing the Swedish AD mutation. The highest level of expression in the brain is found in the cortex, hippocampus, and cerebellum. Starting after the age of 15 months, the rats show increased tau phosphorylation and extracellular Abeta staining. The Abeta is found predominantly in cerebrovascular blood vessels with very rare diffuse plaques. We believe that crossing these animals with mutant PS1 transgenic rats will result in accelerated plaque formation similar to that seen in transgenic mice. |
| Databáze: | OpenAIRE |
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