SARS-CoV-2 infection in acute pancreatitis increases disease severity and 30-day mortality: COVID PAN collaborative study
| Autor: | Pandanaboyana, S., Moir, J., Leeds, J. S., Oppong, K., Kanwar, A., Marzouk, A., Belgaumkar, A., Gupta, A., Siriwardena, A. K., Haque, A. R., Awan, A., Balakrishnan, A., Rawashdeh, A., Ivanov, B., Parmar, C., Halloran, C. M., Caruana, C., Borg, C. -M., Gomez, D., Damaskos, D., Karavias, D., Finch, G., Ebied, H., Pine, J. K., Skipworth, J. R. A., Milburn, J., Latif, J., Ratnam Apollos, J., El Kafsi, J., Windsor, J. A., Roberts, K., Wang, K., Ravi, K., Coats, M. V., Hollyman, M., Phillips, M., Okocha, M., Wilson, M. S. J., Ameer, N. A., Kumar, N., Shah, N., Lapolla, P., Magee, C., Al-Sarireh, B., Lunevicius, R., Benhmida, R., Singhal, R., Balachandra, S., Demirli Atlcl, S., Jaunoo, S., Dwerryhouse, S., Boyce, T., Charalampakis, V., Kanakala, V., Abbas, Z., Nayar, M., Mingoli, A., Brachini, G., Cirillo, B. |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty acute pancreatitis Organ Dysfunction Scores International Cooperation Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pancreatitis Comorbidity Severity of Illness Index Cohort Studies Disease severity Internal medicine Outcome Assessment Health Care Humans Medicine Mortality COVID-19 Respiratory Distress Syndrome SARS-CoV-2 business.industry Gastroenterology Length of Stay Middle Aged medicine.disease Intensive Care Units 30 day mortality Disease Progression Acute pancreatitis Female business |
| Zdroj: | Gut |
| Popis: | ObjectiveThere is emerging evidence that the pancreas may be a target organ of SARS-CoV-2 infection. This aim of this study was to investigate the outcome of patients with acute pancreatitis (AP) and coexistent SARS-CoV-2 infection.DesignA prospective international multicentre cohort study including consecutive patients admitted with AP during the current pandemic was undertaken. Primary outcome measure was severity of AP. Secondary outcome measures were aetiology of AP, intensive care unit (ICU) admission, length of hospital stay, local complications, acute respiratory distress syndrome (ARDS), persistent organ failure and 30-day mortality. Multilevel logistic regression was used to compare the two groups.Results1777 patients with AP were included during the study period from 1 March to 23 July 2020. 149 patients (8.3%) had concomitant SARS-CoV-2 infection. Overall, SARS-CoV-2-positive patients were older male patients and more likely to develop severe AP and ARDS (pConclusionPatients with AP and coexistent SARS-CoV-2 infection are at increased risk of severe AP, worse clinical outcomes, prolonged length of hospital stay and high 30-day mortality. |
| Databáze: | OpenAIRE |
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