PLA-PEG Micelles Loaded with a Classic Vasodilator for Oxidative Cataract Prevention
| Autor: | Yun-Xia Sun, Wen-Long Liu, Lu Xu, Chi Zhang, Mei-Zhen Zou, Wen-Xiu Qiu, Xian-Zheng Zhang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
genetic structures
Biocompatibility medicine.drug_class medicine.medical_treatment 0206 medical engineering Biomedical Engineering chemistry.chemical_element macromolecular substances 02 engineering and technology Calcium channel blocker Calcium Pharmacology medicine.disease_cause Micelle Biomaterials Nifedipine medicine technology industry and agriculture Eye drop 021001 nanoscience & nanotechnology 020601 biomedical engineering eye diseases Bioavailability chemistry sense organs 0210 nano-technology Oxidative stress medicine.drug |
| Zdroj: | ACS biomaterials scienceengineering. 5(2) |
| ISSN: | 2373-9878 |
| Popis: | The only treatment for cataract in clinic is the clouded lens removal combined with artificial lens implantation. In this study, nifedipine (NFP), a classic vasodilator, was loaded in a U.S. FDA-approved polymer PLA–PEG to form NFP-loaded PLA–PEG micelles as a novel eye drop to prevent oxidative cataract formation and progression at the early stage. The NFP-loaded PLA–PEG micelles not only showed satisfactory biocompatibility and bioavailability, but also efficiently improved the anticataract ability through the inhibition of extracellular calcium ions influx. This study may provide a new insight into the development of cataract treatment. |
| Databáze: | OpenAIRE |
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