Dynamic optical coherence tomography of histamine induced wheals

Autor:	F. H. Birch-Johansen, Lotte Themstrup, Jonas Olsen, Gregor B.E. Jemec, J. Holmes
Rok vydání:	2018
Předmět:	Adult Male Noninvasive imaging Urticaria Dermatology 01 natural sciences 010309 optics 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Optical coherence tomography 0103 physical sciences Healthy volunteers Humans Medicine Skin integumentary system medicine.diagnostic_test business.industry Attenuation Blood flow Quantitative measure Forearm chemistry Attenuation coefficient Microvessels Female sense organs business Tomography Optical Coherence Histamine Biomedical engineering
Zdroj:	Skin Research and Technology. 24:592-598
ISSN:	0909-752X
DOI:	10.1111/srt.12470
Popis:	BACKGROUND Dynamic optical coherence tomography (D-OCT) is a noninvasive imaging technique providing images of the skin and detecting movement in the tissue ie, measuring blood flow. The "attenuation coefficient" describes light absorption and scattering abilities of the tissue, while the dynamic signal provides a quantitative measure of the blood flow. AIM The study objective is to describe the dynamic changes of the skin and skin vessels during histamine release using D-OCT. METHODS Healthy volunteers had local histamine injections in the skin and D-OCT-scans performed at 2-minute intervals to detect changes in blood flow, attenuation and clinical symptoms. RESULTS 9/10 participants showed clinical wheals. An increase in blood flow was shown at all depths (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e9d3ac9c5c5d4494990993396d4cf18 https://doi.org/10.1111/srt.12470 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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