Is there association between vitamin D levels, apelin 36, and visfatin in PCOS?

Autor:	Ayşe Yeşim Göçmen, Levent Seçkin, M. Fevzi Polat, Nagihan Sari, Asli Metin, Mustafa Kara, Emel Kiyak Caglayan, Yaprak Engin-Ustun
Rok vydání:	2016
Předmět:	Adult medicine.medical_specialty Endocrinology Diabetes and Metabolism Adipokine 030209 endocrinology & metabolism Ovary vitamin D deficiency Young Adult 03 medical and health sciences 0302 clinical medicine Endocrinology Insulin resistance Adipokines Obstetrics and gynaecology Internal medicine medicine Vitamin D and neurology Humans Vitamin D Nicotinamide Phosphoribosyltransferase 030219 obstetrics & reproductive medicine business.industry Obstetrics and Gynecology medicine.disease Lipids Polycystic ovary Apelin medicine.anatomical_structure Cytokines Intercellular Signaling Peptides and Proteins Female Insulin Resistance business Polycystic Ovary Syndrome
Zdroj:	Gynecological Endocrinology. 32:386-389
ISSN:	1473-0766 0951-3590
DOI:	10.3109/09513590.2015.1124260
Popis:	We aimed to evaluate vitamin D, apelin-36, and visfatin levels in patients with polycystic ovary syndrome (PCOS).The study was completed in six months, including a total of 110 patients who were admitted to the obstetrics and gynecology polyclinic. Patients with a diagnosis of PCOS were divided into two subgroups according to their vitamin D levels. Thirty-four patients had 10 ng/ml of vitamin D deficiency and 21 patients had 10-30 ng/ml of vitamin D insufficiency, with each being defined as a subgroup.Average apelin-36 and visfatin levels in PCOS patients were 2.52 ± 0.68 nmol/L and 72.63 ± 22:31 ng/ml, in the control group they were 0.92 ± 0.33 nmol/L, 24.66 ± 6 ng/ml, respectively. The difference found in PCOS patients was statistically significant (p = 0.0001, p = 0.0001).In conclusion, the present study shows that in PCOS patients with low levels of vitamin D, insulin resistance is greater and apelin-36 serum levels were significantly higher. Although there are different opinions in the literature on this subject, we believe that when vitamin D levels are brought to an optimal level in PCOS patient, it can prevent the negative effects of adipokines in the pathogenesis of PCOS.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e9c32c2d25900d254fefe5ca1fed280 https://doi.org/10.3109/09513590.2015.1124260 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.