Increased risk of cirrhosis and its decompensation in chronic hepatitis C patients with new-onset diabetes: A nationwide cohort study
| Autor: | Jui Ting Hu, Cheng Kai Hsu, Szu Chieh Fu, Yi Wen Huang, Ding-Shinn Chen, Ting Chuan Wang, Jia-Horng Kao, Sien-Sing Yang |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Time Factors Cirrhosis Taiwan Cohort Studies Diabetes Complications Young Adult Internal medicine Diabetes mellitus Humans Medicine Cumulative incidence Decompensation Aged Proportional Hazards Models Aged 80 and over Hepatology business.industry Hazard ratio Hepatitis C Hepatitis C Chronic Middle Aged medicine.disease Surgery Cohort Female business Cohort study |
| Zdroj: | Hepatology. 60:807-814 |
| ISSN: | 0270-9139 |
| DOI: | 10.1002/hep.27212 |
| Popis: | The effect of diabetes on cirrhosis, its decompensation, and their time relationship in chronic hepatitis C (CHC) patients remains unclear. We conducted a nation-wide cohort study by using the Taiwanese National Health Insurance Research Database, which is comprised of data from >99% of the entire population. Among having randomly sampled 1 million enrollees, 6,251 adult CHC patients were identified from 1997 to 2009. Diabetes was defined as new onset in CHC patients who were given the diagnosis in the years 1999-2003, but not in 1997-1998. The cohorts of CHC with new-onset diabetes (n = 424) and nondiabetes (n = 1,708) were followed up from inception point in diabetes and from year 1999 in the nondiabetes cohort until development of cirrhosis or its decompensation, withdrawal from insurance, or December 2009. Kaplan-Meier's survival analysis showed a significantly higher cumulative incidence of cirrhosis (relative risk [RR] = 1.53; 95% confidence interval [CI] = 1.11-2.11; log-rank test; P |
| Databáze: | OpenAIRE |
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