Expanding the role of bacterial vaccines into life-course vaccination strategies and prevention of antimicrobial-resistant infections
| Autor: | Poolman, Jan T. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
lcsh:Immunologic diseases. Allergy Immunology Immune senescence Review Article Skin infection lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine Antibiotic resistance Medicine Pharmacology (medical) 030212 general & internal medicine Pharmacology Vaccines business.industry Circulating antibodies medicine.disease Antimicrobial lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Vaccination Bacterial vaccine 030104 developmental biology Infectious Diseases Life course approach Bacterial infection business lcsh:RC581-607 |
| Zdroj: | npj Vaccines, Vol 5, Iss 1, Pp 1-12 (2020) NPJ Vaccines |
| ISSN: | 2059-0105 |
| Popis: | A crisis in bacterial infections looms as ageing populations, increasing rates of bacteraemia and healthcare-associated infections converge with increasing antimicrobial resistance and a paucity of new antimicrobial classes. New initiatives are needed to develop bacterial vaccines for older adults in whom immune senescence plays a critical role. Novel vaccines require an expanded repertoire to prevent mucosal diseases such as pneumonia, skin and soft tissue infections and urinary tract infections that are major causes of morbidity and mortality in the elderly, and key drivers of antimicrobial resistance. This review considers the challenges inherent to the prevention of bacterial diseases, particularly mucosal infections caused by major priority bacterial pathogens against which current vaccines are sub-optimal. It has become clear that prevention of many lung, urinary tract and skin infections requires more than circulating antibodies. Induction of Th1/Th17 cellular responses with tissue-resident memory (Trm) cells homing to mucosal tissues may be a pre-requisite for success. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|