Subarticular Inflammatory Pseudoabscesses
| Autor: | Lingxin Zhang, Serene Z. Mirza, Edward F. DiCarlo |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Neutrophils Biopsy medicine.medical_treatment Inflammatory arthritis Pannus Bone and Bones Pathology and Forensic Medicine Arthritis Rheumatoid Diagnosis Differential Young Adult Predictive Value of Tests Synovitis Arthropathy medicine Humans Child Aged Retrospective Studies Aged 80 and over business.industry Osteomyelitis Middle Aged medicine.disease Arthroplasty Abscess Rheumatoid arthritis Female Joints Surgery Septic arthritis Anatomy business |
| Zdroj: | American Journal of Surgical Pathology. 44:633-640 |
| ISSN: | 0147-5185 |
| Popis: | Abnormal accumulation of neutrophils in a subarticular bone usually raises the concern for osteomyelitis or septic arthritis, a disabling and potentially life-threatening medical condition. At the pathology department of a specialized orthopedic institute, we observed a distinct pattern of subarticular inflammation mimicking infection characterized by collections of neutrophils, macrophages, and fibrin in pseudocystic spaces of variable size and extent in the superficial subarticular bone not accompanied by granulation tissue or necrosis. We coined the term "inflammatory pseudoabscess" to describe these accumulations. From 1997-2015, we reported inflammatory pseudoabscesses in 157 primary arthroplasty/osteotomy specimens from 143 patients without penetrating trauma or hardware in the affected joint. The predominant gross and histologic features were those of destructive/inflammatory joint disease, including lymphoplasmacytic synovitis (95.3%), subchondral osseous chronic inflammation (80.3%), exudative synovitis (58.0%), synovial pannus (52.0%), and marginal erosions of articular cartilage and/or subarticular bone (43.3%). Clinical information was available in 137 (95.8%) patients, 107 (overall: 74.8%) of whom had preoperatively or postoperatively diagnosed inflammatory arthropathy, most commonly rheumatoid arthritis. The remaining 30 (overall: 21.0%) patients had no documented inflammatory disorders, but some had bilateral or multijoint arthropathy, hands/feet involvement, lymphoplasmacytic synovitis, ulcerative colitis, or family history of inflammatory arthropathy. There was no documented infection-associated implant failure. We believe that inflammatory pseudoabscess represents an intraosseous manifestation of noninfectious inflammatory disorders of joints. This feature should be recognized by pathologists and used to suggest further clinical evaluation for undiagnosed inflammatory joint diseases. |
| Databáze: | OpenAIRE |
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