Mice Producing Reduced Levels of Insulin-Like Growth Factor Type 1 Display an Increase in Maximum, but not Mean, Life Span
| Autor: | Claudio Torres, Susan M. Motch, Christian Sell, Roger McCarter, Antonello Lorenzini, Adam B. Salmon, Yuji Ikeno, Chad A. Lerner |
|---|---|
| Přispěvatelé: | A. Lorenzini, A. B. Salmon, C. Lerner, C. Torre, Y. Ikeno, S. Motch, R. McCarter, C. Sell |
| Rok vydání: | 2013 |
| Předmět: |
Aging
medicine.medical_specialty Genotype medicine.medical_treatment media_common.quotation_subject Longevity Growth hormone receptor Biology Mice Insulin-like growth factor LIFE SPAN Internal medicine medicine Insulin Animals Obesity Insulin-Like Growth Factor I Receptor Maximum life span media_common Gene Expression Regulation Developmental Somatomedin GH Mice Inbred C57BL Metabolism Endocrinology Cohort IGF-1 Original Article Female Geriatrics and Gerontology Gluconeogenesi |
| Zdroj: | The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 69:410-419 |
| ISSN: | 1758-535X 1079-5006 |
| Popis: | Reduced signaling through the IGF type 1 (IGF-1) receptor increases life span in multiple invertebrate organisms. Studies on mammalian longevity suggest that reducing levels of IGF-1 may also increase life span. However, the data are conflicting and complicated by the physiology of the mammalian neuroendocrine system. We have performed life-span analysis on mice homozygous for an insertion in the Igf1 gene. These mice produce reduced levels of IGF-1 and display a phenotype consistent with a significant decrease in IGF-1. Life-span analysis was carried out at three independent locations. Although the life-span data varied between sites, the maximum life span of the IGF-1-deficient mice was significantly increased and age-specific mortality rates were reduced in the IGF-1-deficient mice; however, mean life span did not differ except at one site, where mean life span was increased in female IGF-1-deficient animals. Early life mortality was noted in one cohort of IGF-1-deficient mice. The results are consistent with a significant role for IGF-1 in the modulation of life span but contrast with the published life-span data for the hypopituitary Ames and Snell dwarf mice and growth hormone receptor null mice, indicating that a reduction in IGF-1 alone is insufficient to increase both mean and maximal life span in mice. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|