The mechanism of solifenacin release from a pH-responsive ion-complex oral suspension in the fasted upper gastrointestinal lumen
| Autor: | Maria Vertzoni, Kei Motonaga, Niels Ouwerkerk, Christos Reppas, Yoshifumi Katakawa, Daisuke Murayama, Yosuke Yamamoto, Moe Haneda, Tomokazu Tajiri, Harumi Kumagai |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
food.ingredient
Administration Oral Pharmaceutical Science Lumen (anatomy) 02 engineering and technology 030226 pharmacology & pharmacy Lecithin 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine food Suspensions Intestine Small medicine Humans Particle Size Ion-exchange resin Chromatography Solifenacin Chemistry technology industry and agriculture Cationic polymerization Fasting Solifenacin Succinate Hydrogen-Ion Concentration 021001 nanoscience & nanotechnology Taurocholic acid Small intestine Drug Liberation medicine.anatomical_structure Intestinal Absorption Solubility Gastric Mucosa Particle size 0210 nano-technology medicine.drug |
| Zdroj: | European Journal of Pharmaceutical Sciences. 142:105107 |
| ISSN: | 0928-0987 |
| DOI: | 10.1016/j.ejps.2019.105107 |
| Popis: | The main objective of this study was to investigate the mechanism of solifenacin release from a pH-responsive ion-complex oral resinate suspension under conditions simulating the environment in the upper gastrointestinal lumen. A secondary objective was to propose an appropriate in vitro methodology for evaluating the quality of orally administered solifenacin suspensions. The mechanism of solifenacin release from polacrilin potassium resin (Amberlite® IRP88) was investigated using biorelevant media and compendial setups (USP Apparatus 2 and USP Apparatus 4) and using newer, recently validated in vitro methodologies [biorelevant gastrointestinal transfer (BioGIT) system]. We evaluated the impact of particle size and concentration of the resin; thickener concentration (carbomer homopolymer, type B); and the impact of pH, cationic strength, agitation intensity and level of simulation of contents in the upper gastrointestinal lumen. Data suggested that solifenacin release from the resinate was determined by the resin particle size, the medium pH, cationic strength (when the conditions in the upper small intestine are simulated) and the level of simulation of contents in the upper small intestine. The interaction of solifenacin with taurocholic acid/lecithin aggregates was significant, but unlikely to affect the degree of solifenacin absorption, as a BCS Class I compound. Under acidic conditions, solifenacin was dissociated and released from the pH-responsive resin rapidly. Under conditions simulating the contents of the upper small intestine, solifenacin was replaced by cations from the testing media and diffused through the resin matrix. All three in vitro systems with or without a pH gradient are useful in distinguishing solifenacin release characteristics from resinate suspensions with different particle sizes. Because of this drug release mechanism, USP Apparatus 2 with fixed pH media demonstrated equivalent or slightly higher discriminative sensitivity than the other setups and appears to be appropriate for product quality control. |
| Databáze: | OpenAIRE |
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