The Effects of Added Hydrogen on Noble Gas Discharges Used as Ambient Desorption/Ionization Sources for Mass Spectrometry
| Autor: | Wade C. Ellis, Paul B. Farnsworth, Charlotte R. Lewis, Anna P. Openshaw |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Argon
Hydrogen Chemistry 010401 analytical chemistry Analytical chemistry Noble gas chemistry.chemical_element Dielectric barrier discharge 010402 general chemistry Mass spectrometry 01 natural sciences Ion source 0104 chemical sciences Physics::Plasma Physics Structural Biology Ionization Physics::Atomic and Molecular Clusters Spectroscopy Helium |
| Zdroj: | Journal of the American Society for Mass Spectrometry. 27:1539-1549 |
| ISSN: | 1044-0305 |
| DOI: | 10.1007/s13361-016-1432-y |
| Popis: | We demonstrate the effectiveness of using hydrogen-doped argon as the support gas for the dielectric barrier discharge (DBD) ambient desorption/ionization (ADI) source in mass spectrometry. Also, we explore the chemistry responsible for the signal enhancement observed when using both hydrogen-doped argon and hydrogen-doped helium. The hydrogen-doped argon was tested for five analytes representing different classes of molecules. Addition of hydrogen to the argon plasma gas enhanced signals for gas-phase analytes and for analytes coated onto glass slides in positive and negative ion mode. The enhancements ranged from factors of 4 to 5 for gas-phase analytes and factors of 2 to 40 for coated slides. There was no significant increase in the background. The limit of detection for caffeine was lowered by a factor of 79 using H2/Ar and 2 using H2/He. Results are shown that help explain the fundamental differences between the pure-gas discharges and those that are hydrogen-doped for both argon and helium. Experiments with different discharge geometries and grounding schemes indicate that observed signal enhancements are strongly dependent on discharge configuration. Graphical Abstract ᅟ. |
| Databáze: | OpenAIRE |
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