Behavioral activity of met-enkephalin and ACTH4-10 and other peptides containing a phenylalanine and methionine residue
| Autor: | H. M. Greven, Henk Rigter, Jan W. van Nispen, Joe L. Martinez |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Met-enkephalin
Male Enkephalin Methionine Biophysics Phenylalanine Avoidance response Biochemistry Peptides Cyclic Residue (chemistry) chemistry.chemical_compound Structure-Activity Relationship Adrenocorticotropic Hormone Oral administration Avoidance Learning Animals Molecular Biology chemistry.chemical_classification Methionine Chemistry Cell Biology Enkephalins Cyclic peptide Peptide Fragments Rats Time course Endorphins |
| Zdroj: | Biochemical and biophysical research communications. 98(2) |
| ISSN: | 0006-291X |
| Popis: | Met-enkephalin, injected i.p. 5 minutes before training, decreased acquisition of a step-up active avoidance response in rats. ACTH4–10 exerted a similar effect if given i.p. within 15 minutes of training. ACTH4–10 and Met-enkephalin share a phenylalanine and a methionine residue. The possibility was studied that these amino acid residues are a structural requirement for this effect. Accordingly, some linear and cyclic peptides sharing the sequence Phe-Met were synthesized and tested. The cyclic peptide cyclo (-Phe-Met-e-Ahx-) decreased acquisition but with a longer time course of efficacy than for ACTH4–10 or Met-enkephalin and also after oral administration. |
| Databáze: | OpenAIRE |
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