Comparative genome analysis and characterization of a MDR Klebsiella variicola
| Autor: | Govindan Rajamohan, Vijaya Bharathi Srinivasan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
0303 health sciences Klebsiella Virulence Prophages Drug resistance Biology biology.organism_classification 01 natural sciences Klebsiella variicola Genome Microbiology 03 medical and health sciences Phenotype Antibiotic resistance Drug Resistance Multiple Bacterial Operon Gene cluster Genetics Gene Genome Bacterial 030304 developmental biology 010606 plant biology & botany |
| Zdroj: | Genomics. 112:3179-3190 |
| ISSN: | 0888-7543 |
| DOI: | 10.1016/j.ygeno.2020.06.004 |
| Popis: | Klebsiella variicola is an emerging pathogen responsible for causing blood-stream infections, urinary and respiratory tract related diseases in humans. In this report, we describe the genome sequence data and phenotypic characterization of K. variicola strain KV093 isolated from India. Comparative genome sequence analysis revealed the presence of genes linked with virulence, iron acquisition and transport, type 1 and type 3 pili, secretion systems including the capsular gene cluster. The plant-associated genes such as nitrogen fixation, growth and defense mechanisms against oxidative stress were also identified. On performing antibiotic susceptibility testing, growth inhibition, and stress challenge assays it was observed that the drug resistant K. variicola KV093 exhibited cross resistance to various antibiotics, antiseptics, including disinfectants. This report highlights the arsenal of virulence and antibiotic resistance determinants in K. variicola KV093, an effort emphasizing the current pressing need for regular surveillance of K. variicola strains especially in India. |
| Databáze: | OpenAIRE |
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