A pair of new enantiomers of xanthones from the stems and leaves of Cratoxylum cochinchinense

Autor:	Hui-Ming Hua, Dahong Li, Chi Gong, Cui-Cui Jia, Zhan-Lin Li, Hong Chen, Jing Pu
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Circular dichroism Stereochemistry Xanthone 01 natural sciences 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cratoxylum cochinchinense Prenylation Malignant cells Pharmacology Antitumor activity biology Enantiomer Clusiaceae Antitumor lcsh:Other systems of medicine biology.organism_classification lcsh:RZ201-999 030205 complementary & alternative medicine 0104 chemical sciences 010404 medicinal & biomolecular chemistry Complementary and alternative medicine chemistry
Zdroj:	Chinese Medicine, Vol 14, Iss 1, Pp 1-6 (2019)
ISSN:	1749-8546
DOI:	10.1186/s13020-019-0235-z
Popis:	Background The simple and caged xanthones from Clusiaceae showed significant antineoplastic activity. This study aims to identify structural diverse xanthones and search for novel antitumor natural products from this family plants. Methods The structures of new compounds 1a and 1b were elucidated mainly through comprehensive NMR and MS spectroscopic data, and their absolute configurations were determined by the comparison of the experimental and calculated electronic circular dichroism. Results A pair of new xanthone enantiomers, (+)- and (−)-cracochinxanthone A (1a and 1b), along with thirty known analogues (2–31), were isolated from extracts of the stems and leaves of C. cochinchinense. Preliminary biological assay of some isolates against HL-60, PC-3, and MDA-MB-231 cancer cell lines. Conclusion Some isolated xanthones exhibited high sensitivity against three human malignant cell lines and the structure–activity relationship study showed that the prenyl and geranyl units may play an important role in antitumor activity.
Databáze:	OpenAIRE
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