Serum levels and urinary excretion of salusin-α in renal insufficiency
| Autor: | Takuya Watanabe, Takatoshi Koyama, Masayoshi Shichiri, Shigeaki Kimoto, Toshiaki Suguro, Kengo Sato |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Physiology Urinary system Clinical Biochemistry Radioimmunoassay Clinical marker Biochemistry Cellular and Molecular Neuroscience Salusin α Endocrinology Urinary excretion Internal medicine medicine Humans In patient Renal Insufficiency Aged Ultrasonography Aged 80 and over business.industry Middle Aged Highly sensitive Specific radioimmunoassay Carotid Arteries Intercellular Signaling Peptides and Proteins Female business Glomerular Filtration Rate |
| Zdroj: | Regulatory Peptides. 162:129-132 |
| ISSN: | 0167-0115 |
| Popis: | Salusin-alpha was recently shown to exert anti-atherosclerotic effects and its potential role as a clinical marker for atherosclerosis has been proposed. We determined serum salusin-alpha concentrations in 99 patients across a diverse range of renal functions and urinary salusin-alpha excretions in 12 patients with non-dialyzed renal failure using a highly sensitive and specific radioimmunoassay. Serum salusin-alpha concentrations in patients with moderate to advanced renal insufficiency (eGFR30 ml/min/1.73 m(2)) were significantly lower than those with preserved renal function (eGFR60 ml/min/1.73 m(2)) (6.1 + or - 2.4 pmol/l vs. 11.8 + or - 1.1 pmol/l, p0.05). Since renal failure is frequently associated with atherosclerosis, we analyzed the relationship between serum salusin-alpha and eGFR after excluding patients with advanced atherosclerotic diseases. The serum salusin-alpha level was correlated with eGFR values (n = 94, p0.005). Patients with renal insufficiency showed reduced urinary salusin-alpha excretion, but the magnitude of the reduction was less than that for the decrease in serum salusin-alpha. Consequently, their salusin-alpha clearance often exceeded endogenous creatinine clearance levels. In conclusion, the decreased serum concentrations of salusin-alpha, an anti-atherosclerotic peptide, may be associated with impaired renal function, suggesting a potential role of decreased salusin-alpha in the acceleration of atherosclerosis in chronic kidney diseases. Urinary salusin-alpha may originate from the renal tubules, and may not necessarily represent the peptides filtered at the glomerulus. |
| Databáze: | OpenAIRE |
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