Tissue-Specific Regulation of Reactive Oxygen Species by an ATP-Responsive Nanoregulator Enhances Anticancer Efficacy and Reduces Anthracycline-Induced Cardiotoxicity
| Autor: | Jiacheng Pan, Ruoxi Yang, Yadong Liu, Minjie Sun, Chenzi Li, Wei Li, Minghua Zhang, Chenggen Qian, Zhanwei Zhou |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Reactive oxygen species Chemotherapy Cardiotoxicity medicine.medical_treatment Biochemistry (medical) Biomedical Engineering General Chemistry Oxidative phosphorylation medicine.disease_cause Cancer treatment Biomaterials chemistry medicine Cancer research Tissue specific Anthracycline induced cardiotoxicity Oxidative stress |
| Zdroj: | ACS Applied Bio Materials. 3:8000-8011 |
| ISSN: | 2576-6422 |
| DOI: | 10.1021/acsabm.0c01049 |
| Popis: | Chemotherapy plays an important role in cancer treatment, yet its clinical application is inhibited by side effects. Chemotherapeutic agents accumulate at nonspecific sites and induce oxidative stress damage in noncancer tissues. A selective approach would be ideal, which would not only enhance anticancer efficacy in the tumor sites but also reduce chemotherapy-induced adverse effects on normal tissues. Therefore, we reported an adenosine-5'-triphosphate (ATP)-responsive oxidative stress nanoregulator (DePQu-DOX) to achieve the tissue-specific therapy. The DePQu-DOX NPs coloading doxorubicin (DOX) and quercetin (Qu) enhanced oxidative stress in murine breast cancer cells and scavenged DOX-induced oxygen free radicals in normal cardiac myocytes and podocytes. The released Qu could accelerate free radical scavenging more efficiently in oxygen-rich myocardium than in hypoxic tumors. Additionally, the ATP-specific responsiveness of nanocarriers enable cargos to selectively accumulate at tumor sites and decline the accumulation amount at normal tissues, resulting in lower system toxicity and improved anticancer effects. |
| Databáze: | OpenAIRE |
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