Efficacy of cognitive behavioral therapy and physical exercise in alleviating treatment-induced menopausal symptoms in patients with breast cancer: results of a randomized, controlled, multicenter trial

Autor: Hester S. A. Oldenburg, Herman Rijna, Gert-Jan Timmers, Martijn M. Stuiver, Marian B. E. Menke-Pluymers, Jacobien M. Kieffer, Louise M. de Widt-Levert, Henk van der Veen, Maud M. Geenen, Miranda A. Gerritsma, Epie Boven, Gijsbert Heuff, Eric J van Dulken, Myra S. Hunter, Nina Bijker, Saskia F. A. Duijts, Suzan van der Meij, Neil K. Aaronson, Marc van Beurden, Peter W. Plaisier, Alexander M F Lopes Cardozo
Přispěvatelé: APH - Amsterdam Public Health, Master Evidence Based Practice, CCA -Cancer Center Amsterdam, Radiotherapy, Epidemiology and Data Science, Medical oncology, EMGO - Quality of care, CCA - Quality of life, Faculteit der Geneeskunde, Klinische Psychologie (Psychologie, FMG)
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: Journal of clinical oncology, 30(33), 4124-4133. American Society of Clinical Oncology
Journal of Clinical Oncology, 30(33), 4124-4133. American Society of Clinical Oncology
Duijts, S F A, van Beurden, M, Oldenburg, H S, Hunter, M S, Kieffer, J M, Stuiver, M M, Gerritsma, MA, Menke-Pluymers, M B E, Plaisier, P W, Rijna, H, Cardozo, A M F L, Timmers, G, van der Meij, S, van der Veen, H, Bijker, N, de Widt-Levert, L M, Geenen, M M, Heuff, G, van Dulken, E J, Boven, E & Aaronson, N K 2012, ' Efficacy of Cognitive Behavioral Therapy and Physical Exercise in Alleviating Treatment-Induced Menopausal Symptoms in Patients With Breast Cancer: Results of a Randomized, Controlled, Multicenter Trial ', Journal of Clinical Oncology, vol. 30, no. 33, pp. 4124-4133 . https://doi.org/10.1200/JCO.2012.41.8525
ISSN: 0732-183X
DOI: 10.1200/JCO.2012.41.8525
Popis: Purpose The purpose of our study was to evaluate the effect of cognitive behavioral therapy (CBT), physical exercise (PE), and of these two interventions combined (CBT/PE) on menopausal symptoms (primary outcome), body image, sexual functioning, psychological well-being, and health-related quality of life (secondary outcomes) in patients with breast cancer experiencing treatment-induced menopause. Patients and Methods Patients with breast cancer reporting treatment-induced menopausal symptoms (N = 422) were randomly assigned to CBT (n = 109), PE (n = 104), CBT/PE (n = 106), or to a waiting list control group (n = 103). Self-report questionnaires were completed at baseline, 12 weeks, and 6 months. Multilevel procedures were used to compare the intervention groups with the control group over time. Results Compared with the control group, the intervention groups had a significant decrease in levels of endocrine symptoms (Functional Assessment of Cancer Therapy–Endocrine Symptoms; P < .001; effect size, 0.31-0.52) and urinary symptoms (Bristol Female Lower Urinary Tract Symptoms Questionnaire; P = .002; effect size, 0.29-0.33), and they showed an improvement in physical functioning (36-Item Short Form Health Survey physical functioning subscale; P = .002; effect size, 0.37-0.46). The groups that included CBT also showed a significant decrease in the perceived burden of hot flashes and night sweats (problem rating scale of the Hot Flush Rating Scale; P < .001; effect size, 0.39-0.56) and an increase in sexual activity (Sexual Activity Questionnaire habit subscale; P = .027; effect size, 0.65). Most of these effects were observed at both the 12-week and 6-month follow-ups. Conclusion CBT and PE can have salutary effects on endocrine symptoms and, to a lesser degree, on sexuality and physical functioning of patients with breast cancer experiencing treatment-induced menopause. Future work is needed to improve the design and the planning of these interventions to improve program adherence.
Databáze: OpenAIRE
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