Can ultrasound irradiation be a therapeutic option for prostate cancer?
| Autor: | Toshiro Shirakawa, Shian Ying Sung, Noriaki Maeshige, Masato Fujisawa, Katsumi Shigemura, Koichi Kitagawa, Aya Ishii, Zhi-Min Yuan, Yong Ming Yang, Kuan Chou Chen, Saya Yamasaki |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Cell Survival Ultrasonic Therapy Urology Apoptosis 03 medical and health sciences Prostate cancer 0302 clinical medicine In vivo Cell Line Tumor LNCaP medicine Humans Cell Proliferation Cell growth business.industry Therapeutic effect Ultrasound Prostatic Neoplasms Cancer medicine.disease Prostatic Neoplasms Castration-Resistant 030104 developmental biology Oncology 030220 oncology & carcinogenesis PC-3 Cells business |
| Zdroj: | The Prostate. 80:986-992 |
| ISSN: | 1097-0045 0270-4137 |
| DOI: | 10.1002/pros.24030 |
| Popis: | BACKGROUND Focal therapies for prostate cancer (PC) can reduce adverse events and do not lead to androgen-independent progression. Ultrasound could be used for cancer treatments if the repetition frequency is fitted to the purpose. We investigated the possible therapeutic effect of ultrasound irradiation on PC cells. MATERIALS AND METHODS We irradiated two PC cell lines, androgen-dependent LNCaP and -independent PC-3 with ultrasound (3.0 W/cm2 , 3 MHz, irradiation time rate: 20%) for 2 minutes for 1 day or 3 consecutive days at a repetition frequency of 1, 10, or 100 Hz in vitro. Cell proliferation and apoptosis were determined after irradiation. RESULTS Cell proliferation of PC-3 was significantly inhibited after 1 day (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text