Fasted plasma asprosin concentrations are associated with menstrual cycle phase, oral contraceptive use and training status in healthy women
| Autor: | Nicolette C. Bishop, Alexandra L. Shill, Amber N. Leonard, Alice E. Thackray, David J. Stensel |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Physiology Fibrillin-1 030209 endocrinology & metabolism Appetite hormone 03 medical and health sciences Young Adult 0302 clinical medicine Insulin resistance Sex hormone-binding globulin Physiology (medical) Orexigenic Follicular phase medicine Birth control Humans Orthopedics and Sports Medicine Exercise Menstrual Cycle Progesterone biology Estradiol business.industry Public Health Environmental and Occupational Health General Medicine Fasting medicine.disease Pre-menopausal Obesity Polycystic ovary Menstruation Menstrual cycle phase 030104 developmental biology biology.protein Original Article Female business medicine.drug Hormone Contraceptives Oral |
| Zdroj: | European Journal of Applied Physiology |
| ISSN: | 1439-6327 1439-6319 |
| Popis: | Purpose Asprosin, an orexigenic hormone that stimulates hepatic glucose release, is elevated in insulin resistance and associated with obesity. Plasma asprosin concentrations may also be related to female sex hormone levels; higher levels are reported in women with polycystic ovary syndrome (PCOS) but this may be related to peripheral insulin resistance also associated with PCOS. Clarification of female-specific factors influence on the plasma asprosin response is crucial for studies investigating asprosin. Therefore, this study determined the association of menstrual phase, oral contraceptive (OC) use (as a pharmacological influence on sex hormone levels) and training status (as a physiological influence on sex hormone levels) on plasma asprosin levels in pre-menopausal women. Methods Fasting plasma asprosin, 17β-estradiol (E2) and progesterone, were assessed in 32 healthy untrained and trained women with regular menstrual cycles (non-OC; n = 8 untrained, n = 6 trained) or using OC (n = 10 untrained, n = 8 trained) during early follicular, late follicular and mid-luteal menstrual phases (or the time-period equivalent for OC users). Results Asprosin was lower in OC (0.75 ± 0.38 ng mL−1) than non-OC users (1.00 ± 0.37 ng mL−1; p = 0.022). Across a cycle, asprosin was highest in the early follicular equivalent time-point in OC users (0.87 ± 0.37 ng mL−1) but highest in the mid-luteal phase in non-OC users (1.09 ± 0.40 ng mL−1). Asprosin concentrations varied more across a cycle in untrained than trained women, with higher concentrations in the early follicular phase compared to the late follicular and mid-luteal (training status-by-menstrual phase interaction p = 0.028). Conclusion These findings highlight the importance of considering OC use, menstrual cycle phase and to a lesser extent training status when investigating circulating asprosin concentrations in females. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink