Association of antibiotics use in preschool age with atopic and allergic skin diseases in young adulthood: a population-based retrospective cohort study
| Autor: | Xiang Chen, Bin Wu, Yajia Li, Xiaojing Kang, Juan Su, Juan Tao, Shijun Shan, Yi Xiao, Minxue Shen, Jie Li, Yuzhou Huang, Danrong Jing, Xiaohui Wang, Ji Li |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Allergy Pediatrics medicine.medical_specialty Population Eczema Disease Dermatology Dermatitis Atopic Cohort Studies Young Adult Pregnancy medicine Humans Young adult education Child Retrospective Studies adult dermatology education.field_of_study business.industry Infant Retrospective cohort study General Medicine Atopic dermatitis medicine.disease allergy Anti-Bacterial Agents Upper respiratory tract infection Relative risk Child Preschool Medicine Female business |
| Zdroj: | BMJ Open, Vol 11, Iss 9 (2021) BMJ Open |
| ISSN: | 2044-6055 |
| Popis: | BackgroundOveruse and misuse of antibiotics is a public health problem in low-income and middle-income countries. Although the association of antibiotics with atopic and allergic diseases has been established, most studies focused on prenatal exposure and the occurrence of disease in infants or young children.ObjectiveTo investigate the association of preschool use of antibiotics with atopic and allergic skin diseases in young adulthood.DesignPopulation-based retrospective cohort.Setting and participantsThe first-year college students (n=20 123) from five universities were investigated. The sampled universities are located in Changsha, Wuhan, Xiamen, Urumqi and Hohhot, respectively.MethodsWe conducted a dermatological field examination and a questionnaire survey inquiring the participants about the frequency of upper respiratory tract infection (URTI) and the preschool antibiotics use (prior to 7 years old). The two-level probit model was used to estimate the associations, and adjusted risk ratio (aRR) and 95% CI were presented as the effect size.ResultsA total of 20 123 participants with complete information was included in the final analysis. The frequent antibiotics use intravenously (aRR 1.36, 95% CI 1.14 to 1.62) and orally (aRR 1.18, 95% CI 1.01 to 1.38) prior to 7 years old was significantly associated with atopic dermatitis in young adulthood. Similar trends could be observed in allergic skin diseases among those who use antibiotics orally and intravenously, with RRs of 1.16 (95% CI 1.01 to 1.34) and 1.33 (95% CI 1.13 to 1.57), respectively.ConclusionsPreschool URTI and antibiotics use significantly increases the risk of atopic and allergic skin diseases in young adulthood. |
| Databáze: | OpenAIRE |
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