Cutting Edge: Latecomer CD8 T Cells Are Imprinted with a Unique Differentiation Program
| Autor: | Stephen M. Hedrick, Warren N. D'Souza |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adoptive cell transfer
Cell Survival T cell Immunology Population Mice Transgenic CD8-Positive T-Lymphocytes Biology Lymphocyte Activation Article Vesicular stomatitis Indiana virus Immunophenotyping Mice Interleukin 21 Immune system Cell Movement medicine Animals Immunology and Allergy Cytotoxic T cell Lymphocyte Count IL-2 receptor education Antigen-presenting cell Mice Knockout education.field_of_study Cell Differentiation Adoptive Transfer Mice Inbred C57BL medicine.anatomical_structure Immunologic Memory |
| Zdroj: | The Journal of Immunology. 177:777-781 |
| ISSN: | 1550-6606 0022-1767 |
| Popis: | Factors that influence T cell responses, such as Ag load, APCs, costimulatory molecules, and cytokines, dramatically change during the course of an immune response. We observed that antiviral CD8 T cells were not recruited from circulation simultaneously, but over a period of 3–4 days. Consequently, locally resident T cells and those that entered secondary lymphoid tissue later were primed in very different environments. The cells recruited later in the response were imprinted with a unique differentiation program, such that their magnitude of proliferation was reduced and their kinetics of expansion was delayed. In addition, we found that the “latecomer” CD8 T cells displayed a unique surface phenotype indicative of reduced stimulation but were not preferentially recruited into the surviving pool of memory cells. This finding demonstrates that the timing of recruitment of individual T cell clones determines the population dynamics of the subsequent immune response. |
| Databáze: | OpenAIRE |
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