Investigation of C-reactive Protein and D-dimer Findings in Patients with COVID-19

Autor: Hayrullah Yazar, Yildirim Kayacan, Mehmet Özdin
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Bezmiâlem Science, Vol 9, Iss 1, Pp 4-8 (2021)
ISSN: 2148-2373
Popis: Objective: The purpose of this study is to examine the levels of C-reactive protein (CRP) and D-dimer by age and gender in the pandemic caused by the new coronavirus Methods: Coronavirus disease-19 (COVID-19) diagnoses were made according to the results of real-time polymerase chain reaction and lung computed tomography (n=70) In the study, CRP and coagulation were examined as indicators of inflammation, and D-dimer was examined as an indicator of fibrinolytic system activity Patients' age, gender, and CRP and D-dimer values were analyzed with Spearman's rho correlation, whereas the gender factor was analyzed with the Mann-Whitney U test Results: Although D-dimer levels were high in women, there was no statistical significance A correlation was identified between CRP and gender, and the levels in male patients were higher (p=0 049) A positive correlation was found between the patients' age and CRP and D-dimer findings Conclusion: There are two main findings in this study First, age and gender are essential parameters in disease findings due to the COVID-19 pandemic Their importance overlaps with the finding that inflammation is severe in elderly males and that the mortality is higher than in younger individuals Second, the CRP and D-dimer test results can be used as practical and reliable biomarkers for COVID-19 We propose that if these two tests, which are already used routinely, are interpreted with consideration of age and gender, they can be used more efficiently in early diagnosis and isolation (English) [ABSTRACT FROM AUTHOR] Amac: Bu calismanin amaci, yeni koronavirusun neden oldugu pandemide ilk tani konuldugu anda C-reaktif protein (CRP) ve D-dimer duzeylerinin yas ve cinsiyete gore incelenmesidir Yontemler: Gercek zamanli polimeraz zincir reaksiyonu ve akciger bilgisayarli tomografi (n=70) sonuclarina gore COVID-19 tanilari konuldu CRP inflamasyonun gostergeleri olarak, D-dimer ise fibrinolitik sistem aktivitesinin bir gostergesi olarak incelendi Hastalarin yasi, cinsiyeti, CRP ve D-dimer degerleri Spearman'in rho korelasyonu ile analiz edilirken cinsiyet faktoru Mann-Whitney U testi ile analiz edildi Bulgular: Kadinlarda D-dimer duzeyleri yuksek bulundu, ancak istatistiksel olarak anlamlilik tespit edilmedi Erkek hastalarda ise CRP duzeyleri anlamli olarak yuksek bulundu (p=0,049) Hasta yasi ile CRP ve D-dimer arasinda pozitif korelasyon bulundu Sonuc: Calismada iki ana sonuc ortaya cikti Birincisi, yas ve cinsiyetin COVID-19 salgini nedeniyle gerceklesen hastalikta onemli bir parametre oldugudur Bu bulgu, yasli erkeklerde inflamasyonun siddetli oldugu ve genclere gore olum oraninin daha yuksek olmasi bulgusuyla ortusmektedir Ikinci sonuc ise, CRP ve D-dimer testlerinin COVID-19 icin pratik ve guvenilir bir belirtec olabilecegidir Zaten rutin olarak kullanilan bu iki testin yas ve cinsiyet dikkate alinarak yorumlanmasi halinde erken teshis ve izolasyonda daha verimli kullanilabilecegini oneriyoruz (Turkish) [ABSTRACT FROM AUTHOR] Copyright of Bezmialem Science is the property of Galenos Yayinevi Tic LTD STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission However, users may print, download, or email articles for individual use This abstract may be abridged No warranty is given about the accuracy of the copy Users should refer to the original published version of the material for the full abstract (Copyright applies to all Abstracts )
Databáze: OpenAIRE
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