Lipidomic Adaptations in White and Brown Adipose Tissue in Response to Exercise Demonstrate Molecular Species-Specific Remodeling
| Autor: | Aubrey L. Rose, Andrea I. Doseff, Kristin I. Stanford, Francis J. May, Adam C. Lehnig, Niven R. Narain, Michael A. Kiebish, Fei Gao, Lisa A. Baer, Liubov V. Gushchina, Laurie J. Goodyear, Emily Y. Chen, Kawai So |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Adipose Tissue White Adipose tissue Phosphatidic Acids White adipose tissue Phosphatidylserines Biology General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences chemistry.chemical_compound Mice Adipose Tissue Brown Internal medicine Physical Conditioning Animal Brown adipose tissue Lipidomics medicine Animals lcsh:QH301-705.5 Phospholipids Triglycerides exercise Phosphatidylethanolamines Lipid metabolism Shotgun lipidomics Phosphatidic acid Lipidome Lipid Metabolism Adaptation Physiological adipose tissue Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure Endocrinology Biochemistry chemistry lcsh:Biology (General) Phosphatidylcholines lipidomics lipids (amino acids peptides and proteins) |
| Zdroj: | Cell Reports, Vol 18, Iss 6, Pp 1558-1572 (2017) |
| ISSN: | 2211-1247 |
| Popis: | Exercise improves whole-body metabolic health through adaptations to various tissues, including adipose tissue, but the effects of exercise training on the lipidome of white adipose tissue (WAT) and brown adipose tissue (BAT) are unknown. Here, we utilize MS/MSALL shotgun lipidomics to determine the molecular signatures of exercise-induced adaptations to subcutaneous WAT (scWAT) and BAT. Three weeks of exercise training decrease specific molecular species of phosphatidic acid (PA), phosphatidylcholines (PC), phosphatidylethanolamines (PE), and phosphatidylserines (PS) in scWAT and increase specific molecular species of PC and PE in BAT. Exercise also decreases most triacylglycerols (TAGs) in scWAT and BAT. In summary, exercise-induced changes to the scWAT and BAT lipidome are highly specific to certain molecular lipid species, indicating that changes in tissue lipid content reflect selective remodeling in scWAT and BAT of both phospholipids and glycerol lipids in response to exercise training, thus providing a comprehensive resource for future studies of lipid metabolism pathways. |
| Databáze: | OpenAIRE |
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