In vitro bioactivity and cytotoxicity of films based on mesocarp of Orbignya sp. and carboxymethylcellulose as a tannic acid release matrix
| Autor: | Fernando Aécio de Amorim Carvalho, Davi da Silva, Grasielly Rocha Souza, André Luis Menezes Carvalho, José Arimatéia Dantas Lopes, Lívio César Cunha Nunes, Ricardo de Araújo, Humberto Medeiros Barreto, Sean Telles Pereira, Michel Muálem de Moraes Alves, Paulo Michel Pinheiro Ferreira, A. S. Leal, Gláucia Laís Nunes Lopes |
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| Rok vydání: | 2018 |
| Předmět: |
Polymers and Plastics
DPPH Antiprotozoal Agents 02 engineering and technology Absorption (skin) Arecaceae 01 natural sciences Scavenger chemistry.chemical_compound Mice Cell Line Tumor Tannic acid Materials Testing Materials Chemistry medicine Tannin Animals Cytotoxicity Leishmania major chemistry.chemical_classification ABTS 010405 organic chemistry Organic Chemistry Membranes Artificial 021001 nanoscience & nanotechnology 0104 chemical sciences chemistry Carboxymethylcellulose Sodium Fruit Swelling medicine.symptom 0210 nano-technology Tannins Nuclear chemistry |
| Zdroj: | Carbohydrate polymers. 201 |
| ISSN: | 1879-1344 |
| Popis: | This study aims to obtain mesocarp films of Orbignya sp. (MB) and carboxymethylcellulose (CMC) for application as a drug release matrix. Tannic acid (TA) was used as a standard drug. The films were evaluated by infrared, swelling power, TA release profile, bioactivity and in vitro cytotoxicity. Infrared results indicated absorption at 1.205 cm−1, which is characteristic of ester group from the incorporated tannin. The MB-CMC film had 449.15% swelling power, release of 71.01% of TA of the matrix after 24 h. Films showed scavenger activity of radicals DPPH (79.07 ± 1.71% to 82.17 ± 1.94%) and ABTS + (82.20 ± 0.30% to 88.90 ± 1.05). The MB-CMC film also showed in vitro cytotoxicity on sarcoma-180 (91.86 ± 9.97%) and on promastigote forms of Leishmania major (100%). Polymers showed good compatibility in the mixture and the results suggest the films obtained are promising as drug release matrices. |
| Databáze: | OpenAIRE |
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