Induction of Inflammatory Macrophages in the Gut and Extra-Gut Tissues by Colitis-Mediated Escherichia coli
| Autor: | Jianmei Wei, Yanmei Xu, Lei Sui, Yuan Zhang, Hua Zhu, Xi Yang, Rongcun Yang, Yanwen Xiong, Chunze Zhang, Houbao Qi, Yingquan Liu, Xiaomin Su, Yuanyuan Li, Yunhuan Gao |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Immunology 02 engineering and technology Biology Gut flora medicine.disease_cause Pathophysiology Microbiology digestive system Article 03 medical and health sciences NLRC4 medicine Colitis lcsh:Science Escherichia coli Multidisciplinary digestive oral and skin physiology Inflammasome Biological Sciences 021001 nanoscience & nanotechnology medicine.disease biology.organism_classification Cytosol 030104 developmental biology lcsh:Q 0210 nano-technology Dysbiosis medicine.drug |
| Zdroj: | iScience iScience, Vol 21, Iss, Pp 474-489 (2019) |
| ISSN: | 2589-0042 |
| DOI: | 10.1016/j.isci.2019.10.046 |
| Popis: | Summary Inflammatory macrophages play a critical role in gut and extra-gut inflammatory disorders, which may be promoted through the dysbiosis of gut microbiota. However, it is poorly understood how gut microbiota affect inflammatory macrophages. Here, we found that increased Escherichia coli (E. coli) in inflamed colon may induce inflammatory macrophages in gut and extra-gut tissues. These E. coli are different from other commensal and pathogenic E. coli in genomic components and also in ability to induce inflammatory responses. Dominant E. coli from colitic tissues induce gut inflammatory macrophages through a regulating network consisted of IL-18, IFN-γ, IL-12, and IL-22 in gut tissues. These E. coli also directly activate macrophages. Cytosolic inflammasome components PCKδ, NLRC4, caspase8, and caspase1/11 are involved in E. coli-mediated activation in both gut epithelial cells and macrophages. These disclose a novel mechanism for how dysbiosis of gut microbiota in colitis cause inflammatory macrophages related to multiple diseases. Graphical Abstract Highlights • Increased commensal E. coli in colitis induce inflammatory macrophages • Colitic E. coli are different from other commensal and pathogenic E. coli • Gut inflammatory macrophages by E. coli need IL-18, IFN-γ, IL-12, and IL-22 • PCKδ, NLRC4, caspase8, and caspase1/11 are required for E. coli-mediated activation Biological Sciences; Pathophysiology; Immunology; Microbiology |
| Databáze: | OpenAIRE |
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