Scaffold fabrication technologies and structure/function properties in bone tissue engineering
| Autor: | Maurice N. Collins, Kieran Young, Guang Ren, J. Miguel Oliveira, Sandra Pina, Rui L. Reis |
|---|---|
| Přispěvatelé: | Universidade do Minho |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
bones
Materials science Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Bone tissue engineering Biomaterials Immunomodulation Tissue engineering Electrochemistry Bone Scaffolds Science & Technology Electrospinning Structure function Vascularization Bioprinting 021001 nanoscience & nanotechnology Condensed Matter Physics 0104 chemical sciences Electronic Optical and Magnetic Materials Scaffold fabrication 0210 nano-technology |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| Popis: | Bone tissue engineering (BTE) is a rapidly growing field aiming to create a biofunctional tissue that can integrate and degrade in vivo to treat diseased or damaged tissue. It has become evident that scaffold fabrication techniques are very important in dictating the final structural, mechanical properties, and biological response of the implanted biomaterials. A comprehensive review of the current accomplishments on scaffold fabrication techniques, their structure, and function properties for BTE is provided herein. Different types of biomaterials ranging from inorganic biomaterials to natural and synthetic polymers and related composites for scaffold processing are presented. Emergent scaffolding techniques such as electrospinning, freezeâ drying, bioprinting, and decellularization are also discussed. Strategies to improve vascularization potential and immunomodulation, which is considered a grand challenge in BTE scaffolding, are also presented. M.N.C. and G.R. contributed equally to this work. The authors thank the financial support from the Portuguese Foundation for Science and Technology for the funds provided under the distinctions attributed to J.M.O. (IF/01285/2015) and S.P. (CEECIND/03673/2017), and for the project 3BIOMED (ref. JICAM/0001/2017). |
| Databáze: | OpenAIRE |
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